Search Results: adverse-effects-of-engineered-nanomaterials

Adverse Effects of Engineered Nanomaterials

Exposure, Toxicology, and Impact on Human Health

Author: Bengt Fadeel,Antonio Pietroiusti,Anna A. Shvedova

Publisher: Academic Press

ISBN: 0128094907

Category: Medical

Page: 486

View: 7833

Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population. Uses a schematic, non-exhaustive approach to summarizes the most important research data in this field Discusses the health implications of experimental data in nanotoxicology Presents a completely revised edition that focuses on the human health impacts of engineered nanomaterials, including many organ-specific chapters

Adverse Effects of Engineered Nanomaterials

Exposure, Toxicology, and Impact on Human Health

Author: Bengt Fadeel,Antonio Pietroiusti,Anna A. Shvedova

Publisher: Academic Press

ISBN: 0123869404

Category: Medical

Page: 347

View: 2371

An essential reference that discusses occupational exposure and the adverse health effects of engineered nanomaterials and highlights current and future biomedical applications of these nanomaterials in relation to nanosafety. Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine Discusses the health implications and a clinical translation of experimental data in this area Takes a schematic, non-exhaustive approach to summarize the most important research data in this field Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book

Adverse Effects of Engineered Nanomaterials

Exposure, Toxicology, and Impact on Human Health

Author: Bengt Fadeel,Antonio Pietroiusti,Anna A. Shvedova

Publisher: Academic Press

ISBN: 0123869765

Category: Medical

Page: 360

View: 3907

Adverse Effects of Engineered Nanoparticles: A Disease-Oriented Approach provides a systematic evaluation of representative engineered nanomaterial (ENM) of high volume production and of high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies and the general public need to know about nanosafety. This book, written by leading international experts in nanotoxicology and nanmoedicine, gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers and patients. The beneficial applications, both diagnostic and therapeutic, of ENM are also highlighted. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, and the clinical and pathological consequences of such exposure in the human population. Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine Discusses the health implications and a clinical translation of experimental data in this area Takes a schematic, non-exhaustive approach to summarize the most important research data in this field Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book

Engineered Nanoparticles

Structure, Properties and Mechanisms of Toxicity

Author: Ashok K Singh

Publisher: Academic Press

ISBN: 012801492X

Category: Medical

Page: 554

View: 6087

Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity is an indispensable introduction to engineered nanomaterials (ENM) and their potential adverse effects on human health and the environment. Although research in the area of pharmacology and toxicology of ENM is rapidly advancing, a possible correlation between their physicochemical properties and biomedical properties or toxicity is not yet fully understood. This understanding is essential to develop strategies for the safe applications and handling of ENM. The book comprehensively defines the current understanding of ENM toxicity, first describing these materials and their physicochemical properties, and then discussing the toxicological theory and methodology before finally demonstrating the potential impact of ENM on the environment and human health. It represents an essential reference for students and investigators in toxicology, pharmacology, chemistry, material sciences, medicine, and those in related disciplines who require an introduction to ENM and their potential toxicological effects. Provides state-of-the-art physicochemical descriptions and methodologies for the characterization of engineered nanomaterials (ENM) Describes the potential toxicological effects of ENM and the nanotoxicological mechanisms of action Presents how to apply theory to practice in a public health and risk assessment setting

Handbook of Immunological Properties of Engineered Nanomaterials

Author: Marina A. Dobrovolskaia,Scott E. McNeil

Publisher: World Scientific

ISBN: 9814390259

Category: Medical

Page: 692

View: 7410

The Handbook of Immunological Properties of Engineered Nanomaterials provides a comprehensive overview of the current literature, methodologies, and translational and regulatory considerations in the field of nanoimmunotoxicology. The main subject is the immunological properties of engineered nanomaterials. Focus areas include interactions between engineered nanomaterials and red blood cells, platelets, endothelial cells, professional phagocytes, T cells, B cells, dendritic cells, complement and coagulation systems, and plasma proteins, with discussions on nanoparticle sterility and sterilization. Each chapter presents a broad literature review of the given focus area, describes protocols and resources available to support research in the individual focus areas, highlights challenges, and outlines unanswered questions and future directions. In addition, the Handbook includes an overview of and serves a guide to the physicochemical characterization of engineered nanomaterials essential to conducting meaningful immunological studies of nanoparticles. Regulations related to immunotoxicity testing of materials prior to their translation into the clinic are also reviewed.The Handbook is written by top experts in the field of nanomedicine, nanotechnology, and translational bionanotechnology, representing academia, government, industry, and consulting organizations, and regulatory agencies. The Handbook is designed to serve as a textbook for students, a practical guide for research laboratories, and an informational resource for scientific consultants, reviewers, and policy makers. It is written such that both experts and beginners will find the information highly useful and applicable.

Reproductive and Developmental Toxicology

Author: Ramesh C. Gupta

Publisher: Academic Press

ISBN: 0128042400

Category: Medical

Page: 1460

View: 6296

Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Engineered Nanoparticles and the Environment

Biophysicochemical Processes and Toxicity

Author: Baoshan Xing,Chad D. Vecitis,Nicola Senesi

Publisher: John Wiley & Sons

ISBN: 1119275830

Category: Science

Page: 512

View: 7623

Details the source, release, exposure, adsorption, aggregation, bioavailability, transport, transformation, and modeling of engineered nanoparticles found in many common products and applications Covers synthesis, environmental application, detection, and characterization of engineered nanoparticles Details the toxicity and risk assessment of engineered nanoparticles Includes topics on the transport, transformation, and modeling of engineered nanoparticles Presents the latest developments and knowledge of engineered nanoparticles Written by world leading experts from prestigious universities and companies

Toxic Effects of Nanomaterials

Author: Haseeb Ahmad Khan,Ibrahim Abdulwahid Arif

Publisher: Bentham Science Publishers

ISBN: 1608052834

Category: Science

Page: 147

View: 3334

"Toxic Effects of Nanomaterials provides an authoritative work of international experts in the field of nanotoxicology spanning 8 chapters. A key feature of the e-book is a broad coverage of phytotoxicity of nanoparticles, which is largely neglected in man"

Nanoparticles and the Immune System

Safety and Effects

Author: Diana Boraschi,Albert Duschl

Publisher: Academic Press

ISBN: 0124079210

Category: Medical

Page: 138

View: 1819

Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination). Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system

Handbook of Nanosafety

Measurement, Exposure and Toxicology

Author: Ulla Vogel,Kai Savolainen,Qinglan Wu,Martie van Tongeren,Derk Brouwer,Markus Berges

Publisher: Elsevier

ISBN: 0124166628

Category: Medical

Page: 376

View: 4388

Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace. Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM. Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment. Multi-authored book, written by leading researchers in the field of nanotoxicology and nanosafety Features state-of-the-art physical and chemical characterization of engineered nanomaterials (ENM) Develops strategies for exposure assessment, risk assessment and risk management Includes practical case studies and exposure scenarios to demonstrate how you can safely use ENM in the workplace

Phytotoxicity of Nanoparticles

Author: Mohammad Faisal, Quaiser Saquib, Abdulrahman A. Alatar and Abdulaziz A. Al-Khedhairy

Publisher: Springer

ISBN: 3319767089

Category:

Page: N.A

View: 3597

Engineering of Nanobiomaterials

Applications of Nanobiomaterials

Author: Alexandru Grumezescu

Publisher: William Andrew

ISBN: 0323417345

Category: Science

Page: 564

View: 3802

Engineering of Nanobiomaterials presents the most recent information regarding the specific modifications of nanomaterials and of their synthesis methods, in order to obtain particular structures for different biomedical purposes. This book enables the results of current research to reach those who wish to use this knowledge in an applied setting. Engineered nanobiomaterials, designed from organic or inorganic raw materials, offer promising alternatives in many biomedical applications. In this book, eminent researchers from around the world discuss the various applications, including antibacterial therapy, biosensors, cancer therapy, stimuli-responsive drug release, drug delivery, gene therapy and visual prostheses. In each case, advantages, drawbacks and future potential are outlined. This book will be of interest to students, postdoctoral researchers and professors engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. An up-to-date and highly structured reference source for students, researchers and practitioners working in biomedical, biotechnological and engineering fields A valuable guide to recent scientific progress, covering major and emerging applications of nanomaterials in the biomedical field Proposes novel opportunities and ideas for developing or improving engineering technologies in nanomedicine/nanobiology

Cooperation of Liver Cells in Health and Disease

Author: Z. Kmiec

Publisher: Springer Science & Business Media

ISBN: 3642565530

Category: Science

Page: 151

View: 7800

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

A Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials

Author: Committee to Develop a Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,National Materials and Manufacturing Board,Division on Earth and Life Studies,Division on Engineering and Physical Sciences,National Research Council

Publisher: National Academies Press

ISBN: 0309253284

Category: Science

Page: 212

View: 8860

The nanotechnology sector, which generated about $225 billion in product sales in 2009, is predicted to expand rapidly over the next decade with the development of new technologies that have new capabilities. The increasing production and use of engineered nanomaterials (ENMs) may lead to greater exposures of workers, consumers, and the environment, and the unique scale-specific and novel properties of the materials raise questions about their potential effects on human health and the environment. Over the last decade, government agencies, academic institutions, industry, and others have conducted many assessments of the environmental, health, and safety (EHS) aspects of nanotechnology. The results of those efforts have helped to direct research on the EHS aspects of ENMs. However, despite the progress in assessing research needs and despite the research that has been funded and conducted, developers, regulators, and consumers of nanotechnology-enabled products remain uncertain about the types and quantities of nanomaterials in commerce or in development, their possible applications, and their associated risks. A Research Strategy for Environmental, Health, and Safety Aspects of Engineered Nanomaterials presents a strategic approach for developing the science and research infrastructure needed to address uncertainties regarding the potential EHS risks of ENMs. The report summarizes the current state of the science and high-priority data gaps on the potential EHS risks posed by ENMs and describes the fundamental tools and approaches needed to pursue an EHS risk research strategy. The report also presents a proposed research agenda, short-term and long-term research priorities, and estimates of needed resources and concludes by focusing on implementation of the research strategy and evaluation of its progress, elements that the committee considered integral to its charge.

Nanotoxicity

From In Vivo and In Vitro Models to Health Risks

Author: Saura C. Sahu,Daniel A. Casciano

Publisher: John Wiley & Sons

ISBN: 047074779X

Category: Science

Page: 630

View: 1631

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials. Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessment nanotoxicity assessment by gene expression analysis in vivo and in vitro models for nanotoxicity testing mechanisms of nanotoxicity pharmakokinetics of nanomaterials nanotoxicity of foods including food processing, food packaging and food safety nanotoxicity of drugs including drug development and drug delivery nanotoxicity of cosmetics and consumer products health and environmental impact of nanotoxicity safety evaluation of nanomaterials regulatory impact of nanomaterials Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Nanotechnology - Toxicological Issues and Environmental Safety

Author: P.P. Simeonova,N. Opopol,M.I. Luster

Publisher: Springer Science & Business Media

ISBN: 1402060769

Category: Technology & Engineering

Page: 276

View: 2509

This book provides a summary of the state-of-art knowledge on nanomaterials and nanoparticles. It examines toxicological issues, risk assessment and control measures, public participation and educational/ethical issues, as well as institutional mechanisms and status reports from various countries. Coverage also details collaborations in the field of nanotechnology regarding safe application and development.

Nanomaterials in the Environment

Author: Satinder Kaur Brar

Publisher: ASCE Press

ISBN: 9780784414088

Category: Nanotechnology

Page: 642

View: 9148

This text presents the most current knowledge on the environmental impact of materials and products developed using nanotechnology. Although nanomaterials are revolutionising electronics, medicine, transportation and many other industries, they pose risks to living beings and ecosystems that are barely understood. Leading researchers here consider the science of nanomaterials, their behaviour in the environment, risk assessment and toxicology, and the future of nanomaterials.

Implications of Nanotechnology for Environmental Health Research

Author: Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environmental Health Sciences, Research, and Medicine

Publisher: National Academies Press

ISBN: 9780309181907

Category: Technology & Engineering

Page: 70

View: 707

Nanotechnology is often described as an emerging technology - one that not only holds promise for society, but also is capable of revolutionizing our approaches to common problems. Nanotechnology is not a completely new field; however, it is only recently that discoveries in this field have advanced so far as to warrant examination of their impact upon the world around us. Nanotechnology has direct beneficial applications for medicine and the environment, but like all technologies it may have unintended effects that can adversely impact the environment, both within the human body and within the natural ecosystem. How does the science move forward in a way that best protects the public and gets health and safety right the first time? Implications of Nanotechnology for Environmental Health Research identifies the areas in which additional research is needed and the processes by which changes can occur.

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