The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry. Over the last two decades, this methodology has become an indispensable tool for asymmetric synthesis, not only at the academic level, but also on an industrial scale. This well-established textbook on biocatalysis provides a basis for undergraduate and graduate courses in modern organic chemistry, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts—principles of stereoselective transformations, enzyme properties and kinetics—the different types of reactions are explained according to the 'reaction principle', such as hydrolysis, reduction, oxidation, C–C bond formation, etc. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques and modified or artificial enzymes, are treated in a separate section. A final chapter deals with thebasic rules for the safe and practical handling of biocatalysts. In this completely revised 6th edition, emphasis has been given to an improved didactic style including colored graphics in order to facilitate a deeper understanding of the underlying principles. New developments, such as transamination, enzyme promiscuity and applications on industrial scale within the field of 'white biotechnology' are included.
This text is part of the Biochemical and Medicinal Chemistry Series Series Editor: John Mann, Professor of Organic Chemistry, University of Reading The aim of this series of short textbooks is to present full accounts of topics which are at the interface of chemistry and biology, from medicinal chemistry to molecular biology. The topics chosen for inclusion are popular subjects for upper-level undergraduate and postgraduate modular courses, and yet they receive inadequate coverage in traditional textbooks of organic chemistry and of biochemistry. Each text in the series provides a concise and up to date introduction to its subject in an attractive format. Biotransformations utilize biological systems to carry out chemical transformations. The use of both isolated enzymes and whole organisms in biotransformations is considered . Such processes are playing an increasingly important role in both the research laboratory and in industry because biotransformations occur under mild, 'environmentally friendly' conditions and they have a selectivity which often differs from that encountered with syntheses using traditional laboratory reagents.This accessible introduction to this growing field provides an up-to-date account of those situations in which biotransformations may present viable alternatives to purely chemical synthetic routes or be used in a complimentary manner to chemical reagents in a multi-step organic synthesis. Dr Hanson's concise introduction tothis burgeoning field covers, in addition to enzymatic and microbial methods, the biotransformation of drugs in humans. It is suitable as a course text for advanced undergraduate and graduate students of chemistry and the biomedical sciences. No previous knowledge of biotransformations is assumed.
From the laboratory to full-scale commercial production, this reference provides a clear and in-depth analysis of bioreactor design and operation and encompasses critical aspects of the biocatalytic manufacturing process. It clarifies principles in reaction and biochemical engineering, synthetic and biotransformation chemistry, and biocell and enzyme kinetics for successful applications of biocatalysis and bioprocess technologies in the food, chiral drug, vitamin, pharmaceutical, and animal feed industries. Studying reactions from small to supramolecules, this reference provides an abundant supply of end-of-chapter problems to sharpen understanding of key concepts presented in the text.
Renowned for its student-friendly writing style and fresh perspective, this fully updated Second Edition of John McMurry's ORGANIC CHEMISTRY WITH BIOLOGICAL APPLICATIONS provides full coverage of the foundations of organic chemistry enhanced by biological examples throughout. Based on user feedback, McMurry continues to discuss the organic chemistry of biological pathways and now adds two dozen additional organic chemistry topics, as well as new problems, new illustrations, and new essays. Media integration with OWL for Organic Chemistry, a customizable online learning system and assessment tool, reduces faculty workload, facilitates instruction, and helps students master concepts through tutorials, simulations, and algorithmically generated homework questions. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.
Comprehensive and up–to–date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene–promoted MCRs and frequently applied metal–catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a "who′s who" in multicomponent reaction chemistry, this is definitely a must–have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.
An organic chemist considering the use of enzymes has to solve the problem of knowing which enzyme to use. The focus of this book is, first, on the most useful enzymes - hydrolases. Second, it contains an extensive listing of the known applications. Organic chemists will be able to make reasonable choices by analogy. Third, it contains summaries of the structures of hydrolases and shows how these structures can rationalize the observed selectivities. This provides another way for chemists to choose hydrolases. Fourth, it contains experimental guidelines for how to use the hydrolases. This book will get organic chemists (and enzymologists) started quickly in solving their synthetic problems.