Search Results: cancer-chemotherapy-basic-science-to-the-clinic

Cancer Chemotherapy

Basic Science to the Clinic

Author: Rachel Airley

Publisher: John Wiley & Sons

ISBN: 0470092564

Category: Medical

Page: 342

View: 1490

This textbook is a clear and accessible introduction to the scientific and clinical aspects of the creation, development and administration of drugs or drug regimens used in the treatment of cancer. Unique in its approach, this book enables the student to gain an understanding of the pathological, physiological and molecular processes governing malignancy, whilst also introducing the role of health professionals and scientists in the research and treatment of cancer. The book consolidates all the essential information necessary for a full understanding of cancer chemotherapy, providing an informative, inexpensive and up-to-date coverage of the subject aimed at an undergraduate level readership. Key Features: Incorporates numerous diagrams, tables and illustrations to aid understanding. Examines key pharmacological and pharmaceutical issues such as dosing, toxicity and preparation of anti-cancer drugs. Includes a key chapter of practice essay questions to ease revision. Comprehensive coverage of drugs currently in pre-clinical and clinical development. An indispensable text for undergraduate students studying pharmacy and medicine as well as those doing courses such as molecular biology, biomedical sciences and pharmacology which cover aspects of oncology.

Drug Delivery in Oncology

From Basic Research to Cancer Therapy, 3 Volume Set

Author: Felix Kratz,Peter Senter,Henning Steinhagen

Publisher: John Wiley & Sons

ISBN: 3527647759

Category: Medical

Page: 1822

View: 9322

In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.

Critical Thinking: An Introduction to the Basic Skills - American Seventh Edition

Author: William Hughes,Jonathan Lavery,Katheryn Doran

Publisher: Broadview Press

ISBN: 146040470X

Category: Philosophy

Page: 460

View: 2921

Critical Thinking is a comprehensive and accessible introduction to the essential skills of good reasoning. The authors provide a thorough treatment of such central topics as deductive and inductive reasoning, logical fallacies, how to recognize and avoid ambiguity, and how to distinguish what is relevant from what is not. Later chapters discuss the application of critical thinking skills to particular topics and tasks, including scientific reasoning, moral reasoning, media analysis, and essay writing. This seventh edition is revised and updated throughout, and includes a new chapter on legal reasoning as well as access to a companion website of additional questions and other useful resources.

The Cancer Solution

Taking Charge of Your Life with Cancer

Author: Jack C. Westman, M.D., M.S.

Publisher: Archway Publishing

ISBN: 1480813095

Category: Health & Fitness

Page: 310

View: 435

This book should be read as a requirement for anyone diagnosed with cancer. It will serve as a tremendous practical guide for cancer patients and their families. —Thomas N. Seyfried, Professor of biology at Boston College and author of Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer. This book is a “must read” for every adult as cancer remains our greatest enemy. If you have experience with cancer, via a family member or friend, once you start reading this book, it will be hard to put down. —Peter L. Pedersen, Professor of Biological Chemistry & Oncology, Johns Hopkins University. Dr. Westman’s personal experience with cancer led him to extensively research the state of cancer care. Strengthening the body’s own immune system to prevent and control cancer has shown very promising results, but it is largely ignored by mainstream cancer research and treatment. If you care about winning the war on cancer, this book will motivate you to advocate for more funding for this line of research. —Stephen L. Swanson, Past Chair of the Board of Directors of the American Cancer Society Dr. Westman’s book is amazing, creative, innovative, different, stimulating and outstanding. —Bharat B. Aggarwal, Professor of Cancer Research, University of Texas M. D. Anderson Cancer Center.

Cancer and Aging

From Bench to Clinics

Author: Martine Extermann

Publisher: Karger Medical and Scientific Publishers

ISBN: 331802306X

Category: Medical

Page: 170

View: 6069

Outlining the complex interaction between the two phenomena Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty. This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.

Adult and Embryonic Stem Cells

Author: Kursad Turksen

Publisher: Springer Science & Business Media

ISBN: 1617796301

Category: Science

Page: 262

View: 7703

This volume will cover a series of reviews on stem cells including adult and embryonic stem cells. Speakers were invited to present these talks during the Stem Cell Symposia in fall of 2010, in Samsun, Turkey. Unique aspect of this volume is that it brings a multidisciplinary aspect of stem cells extracted from a symposium.

Immunity, Cancer, and Chemotherapy

Basic Relationship on the Cellular Level

Author: Enrico Mihich

Publisher: Elsevier

ISBN: 1483259005

Category: Health & Fitness

Page: 414

View: 6767

Immunity, Cancer, and Chemotherapy focuses on the interference of drugs on antibody response and transplantation immunity. The selection first offers information on the effects of immunosuppressive drugs on cellular changes after antigenic stimulation and specialized cell function in the lymphoid and reticuloendothelial cell series. Topics include effects of immunosuppressive drugs on the sensitization process; cellular changes in lymphoid tissue following sensitization; and demonstration of differences in antigen handling among cells of the reticuloendothelial system. The text also takes a look at allogeneic inhibition and its possible relation to cell-bound immunity in vitro and the effects of immunosuppressive drugs at various stages of differentiation of immunologically competent cells. The publication examines a study of antibody-containing cells in the course of immunization and cellular differentiation during immune responses studied with electron microscope and radioautography. The text also elaborates on ambiguity in the translation of genetic code into proteins, induced by aminoglycoside antibiotics and immunosuppressive agents and cellular kinetics of immune response. The selection is a dependable source of information for readers interested in effects of drugs on antibody response and transplantation immunity.

Current Cancer Research 2002

Author: Deutsches Krebsforschungszentrum

Publisher: Springer Science & Business Media

ISBN: 9783798513426

Category: Medical

Page: 348

View: 3759

Chemotherapy-Induced Neuropathic Pain

Author: Robert B. Raffa,Richard Langford,Joseph V. Pergolizzi, Jr.,Frank Porreca,Ronald J. Tallarida

Publisher: CRC Press

ISBN: 1439862184

Category: Health & Fitness

Page: 233

View: 3045

There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years. Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the important area of chemotherapy-induced neuropathic pain. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment. The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). Through them, the book provides the reader with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.

Treatment of Peritoneal Surface Malignancies, An Issue of Surgical Oncology Clinics, E-Book

Author: Jesus Esquivel

Publisher: Elsevier Health Sciences

ISBN: 1455754250

Category: Medical

Page: 219

View: 3907

This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. Jesus Esquivel, will focus on the current status and future directions of the treatment of the most common peritoneal surface malignancies: appendix cancer, colorectal cancer, ovarian cancer, gastric cancer, and peritoneal mesothelioma. This issue will also outline some of the most common issues that arise regarding cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC), such as pharmacokinetic rationale of heat and intraperitoneal chemotherapy, HIPEC techniques and safety considerations, how to start a peritoneal surface malignancy program, anesthesia considerations during cytoreductive surgery and HIPEC, patient selection for cytoreductive surgery and HIPEC, and the role of dystemic chemotherapy in the management of peritoneal surface malignancies of appendiceal and colorectal origin.

Nutrition and the Cancer Patient

Author: Egidio Del Fabbro,Wendy Demark-wahnefried,Vickie Baracos

Publisher: Oxford University Press, USA

ISBN: 0199550190

Category: Medical

Page: 519

View: 1624

Nutrition, appetite, and involuntary weight loss are issues that affect a large number of cancer patients and cancer survivors. Aspects such as symptom management, behavioural modification, exercise and medication are all important aspects of cancer care, but nutritional issues at the end of life can be accompanied by contentious ethical factors as well as religious and cultural influences that need to be addressed by health professionals. This book enables physicians, nurses and also dieticians to better discuss these complex issues with patients and their families. This comprehensive reference book provides both background information and practical, clinical advice for managing the cancer patient at all stages of their disease trajectory. It includes information that relates to patients who are continuing to receive disease-specific therapy, the cancer survivor, as well as patients with advanced or recurrent cancer receiving palliative care. Basic principles such as epidemiology and physiology set the scene, leading into the cachexia/anorexia syndrome, treatment options, nutritional counselling, enteral and parenteral nutrition, complementary/alternative therapies, exercise, clinical outcomes measures in each of the clinical groups, and focus on special populations and their specific needs. Multidimensional, interdisciplinary clinical evaluation and treatment is emphasised, and ethical, religious, and cultural factors are also addressed. Multidisciplinary in nature, this book draws on the experience of the editors' work across the fields of oncology, palliative care, surgery, primary care, nursing, dietetics and nutritional science. It will prove invaluable to all general practitioners, internists, medical oncologists and surgeons, nurses, palliative care specialists and related professionals involved in the care of the cancer patient.

Flow Cytometry in Drug Discovery and Development

Author: Virginia Litwin,Philip Marder

Publisher: John Wiley & Sons

ISBN: 0470922788

Category: Medical

Page: 360

View: 1205

This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.

DNA Methylation and Cancer Therapy

Author: Moshe Szyf

Publisher: Springer Science & Business Media

ISBN: 9780306478482

Category: Medical

Page: 239

View: 372

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.

Neonatal and Pediatric Clinical Pharmacology, An Issue of Pediatric Clinics - E-Book

Author: John N van den Anker,Max J. Coppes,Gideon Koren

Publisher: Elsevier Health Sciences

ISBN: 1455747386

Category: Medical

Page: 240

View: 6640

The need for safe and effective use of medicines in children and WHO's initiative "Make Medicines Child Size" have boosted research and educational activities in the area of pediatric clinical drug research. This issue focuses on both general and specific aspects of neonatal and pediatric clinical pharmacology including ethics, pharmacogenomics, metabolomics, adverse drug reactions, pain medication, pulmonary hypertension and several other hot topics. The editors have been able to find outstanding authors for the different parts on neonatal and pediatric pharmacology.

Outcomes Research in Surgical Oncology, An Issue of Surgical Oncology Clinics - E-Book

Author: Clifford Ko

Publisher: Elsevier Health Sciences

ISBN: 1455747726

Category: Medical

Page: 240

View: 5226

In this issue of Surgical Oncology Clinics of North America, Guest Editor Clifford Ko, MD has assembled the top experts concerning Outcomes Research in Oncology. Topics in this issue will include: Currently Available Quality Initiatives in Surgical Oncology; Variation in Mortality After High Risk Cancer Surgery: Failure to Rescue; Readmission as a Quality Measure Following High Risk Cancer Surgery; Randomized Controlled Trials in Surgical Oncology: Where Do We Stand?; Lymph Node Staging in GI Malignancies; Racial and Socioeconomic Disparities in Cancer Care; Patient Safety in Surgical Oncology: Perspective from the Operating Room; Value Based Health Care: A Surgical Oncologist Perspective; Monitoring the Delivery of Cancer Care: Commission on Cancer and National Cancer Data Base; Prediction Tools in Surgical Oncology; Collaboration With the Community Cancer Center: Benefit for All; and Evaluating the Appropriateness of Cancer Care in the United States.

Lung Cancer, An Issue of Surgical Oncology Clinics - E-Book

Author: Mark J. Krasna

Publisher: Elsevier Health Sciences

ISBN: 1455712167

Category: Medical

Page: 410

View: 4718

In this issue of Surgical Oncology Clinics of North America, Guest Editor Mark Krasna and colleagues discuss a wide range of topics devoted to lung cancer. Articles focus on pathology; updated staging systems; epidemiology of lung cancer - smoking, second hand smoke, and genetics; molecular markers for incidence, prognosis, and response to therapy; screening; diagnostic work-up; non-invasive staging techniques; surgical resection; the role of surgery following induction therapy for stage III NSCLC; the role of adjuvant chemotherapy in NSCLC (stages I-III); and much more.

Basic Science of Oncology, Fifth Edition

Author: Ian F. Tannock

Publisher: McGraw Hill Professional

ISBN: 0071745203

Category: Medical

Page: 575

View: 4867

Basic Science of Oncology, 5e is an engaging state-of-art review of cancer causation, cancer biology, and the biology underlying cancer treatment. The fifth edition features critical updates in all areas of the fast-moving field of cancer care

New Drugs for Malignancy, An Issue of Hematology/Oncology Clinics of North America - E-Book

Author: Franco Muggia

Publisher: Elsevier Health Sciences

ISBN: 1455744085

Category: Medical

Page: 1440

View: 6154

Topics include: Targeting IGF-1R, Tyrosine Kinase Inhibitors in Lung Cancer, Targeting mTOR, Targeting Hedgehog, Mitotic Inhibitors, Topoisomerase I Inhibitors , and New Strategies and Drugs Inhibiting Folate Pathways.

Skin Cancer: Basic Science, Clinical Research and Treatment

Author: Claus Garbe,Stefan Schmitz,Constantin E. Orfanos

Publisher: Springer Science & Business Media

ISBN: 3642787711

Category: Medical

Page: 440

View: 2509

In the past two decades, considerable interest in skin cancer has developed in the public and scientific communities. There may have been several reasons for this: - The rise in the global incidence of cutaneous cancers - New molecular biology techniques resulting in a better understanding of pathogenesis and improved diagnostic procedures - The advent of new pathological entities, e. g. , the endemic form of Kaposi's sarcoma - A constantly increasing range of therapeutic modalities, providing even more efficacious treatment and manage ment of skin cancers As N. E. Fusenig describes in the first chapter of this volume, basic research is only beginning to unravel the complex mechanism involved in cellular dedifferentiation and tumor progression. Progress is dearly needed, especially in dermato oncology, where the rise in the incidence of epithelial tumors has inflated the overall skin cancer incidence. The incidence of tumors of the skin exceeds that of all other neoplasias in humans, with recreational sun exposure being a suspected primary cause. Several studies on the effects of UV radiation have been included at the beginning of this volume. Even the role of long wavelength UV (UVA) has become a focus of research activities. The main concern is that the low carcinogenicity of UVA, in comparison to UVB, may be outweighed and exceeded in its effects by increased UV A exposure, e. g.

Breast Cancer in Young Women

Author: Nancy Klauber-DeMore

Publisher: IOS Press

ISBN: 9781586036324

Category: Health & Fitness

Page: 121

View: 5427

"This publication is dedicated to a comprehensive overview of breast cancer in young women for all members of the healthcare team who treat women with breast cancer. Breast cancer requires multidisciplinary management, and as such this book provides input from epidemiology, basic science, surgical oncology, radiation oncology, medical oncology, plastic and reconstructive surgery, genetics, reproductive endocrinology, psychology and nursing. Because breast cancer in young women occurs during the reproductive years, additional emphasis is placed on managing breast cancer in pregnant patients, as well as reproductive options for breast cancer survivors. The contributors to this volume comprise 30 experts from 6 academic institutions across 10 disciplines. By presenting a clear and comprehensive review of all aspects of breast cancer treatment in young women, the contributors hope to have provided a valuable resource to assist with patient care for all members of the multidisciplinary breast cancer team."

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