Search Results: excitation-contraction-coupling-and-cardiac-contractile-force-developments-in-cardiovascular-medicine

Excitation-Contraction Coupling and Cardiac Contractile Force

Author: D. M. Bers

Publisher: Springer Science & Business Media

ISBN: 9780792371571

Category: Medical

Page: 427

View: 7676

Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).

Excitation-Contraction Coupling and Cardiac Contractile Force

Author: Donald Bers

Publisher: Springer Science & Business Media

ISBN: 9401715122

Category: Medical

Page: 265

View: 6250

The main aim of this monograph is to provide an overview of calcium regulation in cardiac muscle cells, particularly with respect to excitation-contraction coupling and the control of cardiac contractile force. It is my hope that this book will be useful to students of the cardiovascular system and muscle at all different levels and in different disciplines (such as physiology, biochemistry, pharmacology and pathophysiology). I also hope that it will find use for those studying developmental, comparative and disease processes as well as more integrative phenomenon. I kept several goals in mind in writing this monograph. First, it should be easily readable. Second, I chose to include numerous illustrations and tables to help integrate results from numerous investigators in practical formats and also present key figures from important papers. Thus, this monograph may serve as a resource of information for people working in the areas described herein. Third, the presentation is a very personal one, and I have necessarily drawn extensively on my personal experience in this field over the past 15 years. This, I think, helps maintain a certain continuity of thought from chapter to chapter. Fourth, I have made serious attempts to make each chapter "up to date", despite the breadth of topics covered. I have also tried to be equitable in choosing references while not intending to be comprehensive or exhaustive. Neither of these aims can be perfectly matched, and I apologize to the many investigators whose papers I have not cited, but should have.

Elements of Computational Systems Biology

Author: Huma M. Lodhi,Stephen H. Muggleton

Publisher: John Wiley & Sons

ISBN: 9780470556740

Category: Computers

Page: 400

View: 8735

Groundbreaking, long-ranging research in this emergent field that enables solutions to complex biological problems Computational systems biology is an emerging discipline that is evolving quickly due to recent advances in biology such as genome sequencing, high-throughput technologies, and the recent development of sophisticated computational methodologies. Elements of Computational Systems Biology is a comprehensive reference covering the computational frameworks and techniques needed to help research scientists and professionals in computer science, biology, chemistry, pharmaceutical science, and physics solve complex biological problems. Written by leading experts in the field, this practical resource gives detailed descriptions of core subjects, including biological network modeling, analysis, and inference; presents a measured introduction to foundational topics like genomics; and describes state-of-the-art software tools for systems biology. Offers a coordinated integrated systems view of defining and applying computational and mathematical tools and methods to solving problems in systems biology Chapters provide a multidisciplinary approach and range from analysis, modeling, prediction, reasoning, inference, and exploration of biological systems to the implications of computational systems biology on drug design and medicine Helps reduce the gap between mathematics and biology by presenting chapters on mathematical models of biological systems Establishes solutions in computer science, biology, chemistry, and physics by presenting an in-depth description of computational methodologies for systems biology Elements of Computational Systems Biology is intended for academic/industry researchers and scientists in computer science, biology, mathematics, chemistry, physics, biotechnology, and pharmaceutical science. It is also accessible to undergraduate and graduate students in machine learning, data mining, bioinformatics, computational biology, and systems biology courses.

Cardiovascular System

Author: Roy D. Russ,Toby Fagan,Romeshan Sunthareswaran

Publisher: Mosby Incorporated

ISBN: 9780323043458

Category: Medical

Page: 180

View: 8617

Don't panic! "Crash Course" is here-that perfect set of lecture notes which no student ever really has the time to compile. These books deliver all of the information needed to get through a course or prepare for exams. Clear text covers the essential concepts of each discipline or specialty; learning features expedite mastery of the material; and review questions let readers assess their knowledge. With basic science books written by current medical students under faculty supervision, and clinical titles that pair senior specialists with doctors who have only recently begun training in the relevant field, Crash Course titles are designed to ideally meet the needs of today's medical students. Plus each of these titles includes complimentary access to - where you'll find the full text of the book online...Integration Links to bonus content in other STUDENT CONSULT titles...and much more! Clear, concise, narrative-style text covers exactly what students need to know-no more, no less. Abundant two-color diagrams explain key concepts in an interesting visual way. Learning features such as "hints and tips" and "comprehension check" boxes simplify study. Multiple-choice and short-answer questions at the back of the books facilitate self assessment, and additional USMLE-style review questions are available to purchasers online at

Heart Failure, Second Edition

Author: Marc Semigran,Jordan T. Shin

Publisher: CRC Press

ISBN: 1420077015

Category: Medical

Page: 500

View: 3590

Heart Failure, Second Edition has been updated to provide the latest advancements in heart failure research. Supplemented by more than 200 high-quality figures and illustrations, the book helps cardiologists and emergency care physicians quickly and accurately identify the cause and severity of a patient’s cardiac impairment. New topics in this edition include: Developments in mechanical and pharmacologic treatments Discoveries in developmental biology Up-and-coming imaging modalities Surgical options for mechanical circulatory support and cardiac transplantation Pharmacogenomics and gene-based and cell-based therapies Gene expression/recurrence in heart failure Changes in metabolic substrate utilization and pathways

Factors Influencing Adrenergic Mechanisms in the Heart

Satellite Symposium of the 28th International Congress of Physiological Science, Visegrá, Hungary, 1980

Author: M. Szentiványi,A. Juhász-Nagy

Publisher: Elsevier

ISBN: 148319017X

Category: Science

Page: 276

View: 6498

Advances in Physiological Sciences, Volume 27: Factors Influencing Adrenergic Mechanisms in the Heart is a collection of papers presented at the 1980 satellite symposium of the 28th International Congress of Physiological Science, held in Visegrád, Hungary. This symposium covered the achievements that modify the traditional views of adrenergic regulation of cardiac muscle and coronary blood vessels. This volume is composed 18 chapters and begins with a discussion of the effect of adrenaline on some aspects of electrical and mechanical activity in the frog heart. The subsequent chapters describe the heart rate changes in neurogenic hypertension, the developmental changes of the catecholamine-induced chronotropic responses related to the blood pressure responses, and the inverse reciprocal regulation of cardiac post-synaptic a- and b-adreneceptors by thyroid hormones. Other chapters deal with the mechanism of adenosine-induced inhibition of adrenergic neurotransmission in the ventricular myocardium; the comparative morphological studies of localized exogenous adenosine in heart muscle; adenosine sensitivity of canine coronaries; and the significance of nickel ion in the coronary vascular tone regulation. These chapters are followed by discussions of the physiological and pathological effects of beta modulator release and the histological study of experimental diabetic angiopathy. The last chapters examine some aspects of myocardial noradrenaline metabolism in the ischemic heart and the activity of alpha-adrenoceptor without employing beta blocking agents.

Manual of Ambulatory General Surgery

A Step-by-Step Guide to Minor and Intermediate Surgery

Author: Shukri K. Shami,Delilah Hassanally

Publisher: Springer Science & Business Media

ISBN: 1447107233

Category: Medical

Page: 136

View: 987

A step-by-step guide to the most commonly performed minor operations, mostly done under local anaesthetic on a day case basis, although some may require general anaesthetic. The book is profusely illustrated with clear diagrams, and is designed to be a practical guide rather than an exhaustive reference. For all those who are required to carry out these procedures such as general surgeons, junior doctors, general practitioners and podiatrists, and of interest to medical students.

The Journal of Experimental Biology

Author: N.A

Publisher: N.A


Category: Biology

Page: N.A

View: 6858

Drug Screening Methods

Author: Suresh Kumar Gupta,S. K. Gupta

Publisher: Anshan


Category: Medical

Page: 501

View: 6664

Drug discovery and development is a challenging, expensive and time consuming field of research, requiring contributions from chemists, pharmacologists, toxicologists, clinicians, and practitioners. The ultimate goal is to generate a safe and biologically active drug which can stall, or even reverse, the pathological events that cause the disease condition. But in the search for the drug a host of tests and trials must be applied to evaluate the efficiency and safety of the newly developed molecule in the biological system. These trials or "screening methods" are critical. On their basis, the new molecule either becomes accepted for usage, or is discarded forever. Advances in drug research have forced the need for quicker, more automated screening methods, using molecular techniques applied in vitro, in vivo and in clinical systems. Researchers need to know the latest developments outside their own speciality. With this book, Professor Gupta has brought together in one coherent volume the most up to date developments of consolidated screening methods for biological systems. By paying attention to the practical techniques used in academia and the commercial pharmaceutical industry, "Drug Screening Methods" will enjoy a broad readership, serving both the professional community and the student of pharmacology.

Cardiac Dynamics

Author: J. Baan,A.C. Arntzenius,E.L. Yellin

Publisher: Springer Science & Business Media

ISBN: 940098796X

Category: Medical

Page: 555

View: 6609

Cardiac Dynamics is the name of a relatively young field of study, born from the fruitful interaction between branches of two different disciplines: medicine and physics. "Dynamics" is the branch of physics which deals with the action of forces on bodies or particles in motion or at rest. "Cardiac" relates to the clinical field of cardiology but also to cardiophysiology, both of which are specialized branches of medicine. Narrower than the well established field of Hemodynamics, Cardiac Dynamics is restricted to dynamic phenomena occurring in and around the heart. The mathematical treatment of such phenomena, however, is vastly more complex because of the intricate nature of the mechanisms involved in the cardiac action. Thus, whereas hemodynamics is concerned with predominantly passive (visco-) elastic structures - vessels - containing time-variant flow of viscous flui- blood -, the mechanical study of the heart requires additional con siderations such as: active elastic components representing the contractile mechanism of cardiac muscle, complex geometry and fiber structure in the myocardial wall, autoregulatory mechanisms, and intricate flow patterns associated with valve motion. Viewed in this light it is not surprising that attempts to describe ventricular pump function and to quantify contractile performance have not reached the level of sophistication which is common in e. g. arterial hemodynamics. For the same reason, many of the often simplified approaches to describe ventricular mechanics failed to stand up to more rigorous theoretical, experimental or clinical testing.

Cardiovascular Physiology,Mosby Physiology Monograph Series (with Student Consult Online Access),10

Cardiovascular Physiology

Author: Achilles J. Pappano,Withrow Gil Wier

Publisher: Elsevier Health Sciences

ISBN: 0323086977

Category: Medical

Page: 292

View: 5349

The Mosby Physiology Monograph Series offers the fundamentals of body systems physiology in a clear and concise manner. Each volume in the series is written by experts in the field for an authoritative, yet readable introduction to the physiology relevant to a particular organ system. This new 9th edition of Cardiovascular Physiology offers: . Clear, accurate and up-to-the-minute coverage of the physiology of the cardiovascular system focusing on the needs of the student. . Pathophysiology content throughout that serves as a bridge between normal function and disease. . Integrated student-friendly tools, including learning objectives, overview boxes, key words and concepts, chapter summaries, and clinical cases with questions and explained answers . Access to Student Consult ®! is an innovative website that allows you to build a personalized, fully integrated, online library, where you'll find the entire contents of every STUDENT CONSULT title purchased, integration links to bonus content in other STUDENT CONSULT titles, and much more.

Sex and Gender Differences in Pharmacology

Author: Vera Regitz-Zagrosek

Publisher: Springer Science & Business Media

ISBN: 3642307264

Category: Medical

Page: 602

View: 8267

This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Laboratory Animal Practitioner

Author: N.A

Publisher: N.A


Category: Laboratory animal technicions

Page: N.A

View: 9657

Journal of Experimental Biology

Author: N.A

Publisher: N.A


Category: Biology

Page: N.A

View: 432

Stochastic models of intracellular calcium release and alternans

Author: Robert James Rovetti

Publisher: N.A


Category: Science

Page: 278

View: 5895

Myocardial Viability

Author: A.E. Iskandrian,Ernst E. van der Wall

Publisher: Springer Science & Business Media

ISBN: 9401140804

Category: Medical

Page: 244

View: 5997

AMI E. ISKANDRIAN & ERNST E. VAN DER WALL The first edition of this book was published in 1994. Since then important advances have occurred in the field of myocardial viability. This, coupled with increasing interest by the scientific community in the broader issues of its relevance to patient care, suggested to us the need to write the second edition. We are most fortunate to have the help of a distinguished group of experts who have helped shape the field; we appreciate their commitments and contributions. Almost all chapters have been radically modified. Chapter 1 deals with pathophysiology of myocardial hibernation and stunning; Chapter 2 with apoptosis; Chapter 3 with the role of positron emission tomography; Chapters 4 and 5 with the role of single photon emission computed tomography with thallium-201 and technetium agents, respectively; Chapter 6 with the role of SPECT fatty acid imaging; Chapter 7 with the role of SPECT FDG imaging; Chapter 8 with the role of cardiac catheterization angiography; Chapter 9 with the role of echocardiography; Chapter 10 with the role of magnetic resonance imaging; and Chapter 11 with clinical applications. Finally, Chapter 12 provides a short summary.

The ECG in Acute Myocardial Infarction and Unstable Angina

Author: Hein J.J. Wellens,Anton M. Gorgels,Pieter A. Doevendans

Publisher: Springer Science & Business Media

ISBN: 1402072147

Category: Medical

Page: 132

View: 6264

This volume, written by the leaders in the field, will provide a practical and comprehensive overview of the electrocardiogram (ECG). The ECG remains the most accessible and inexpensive diagnostic tool to evaluate the patient presenting with symptoms suggestive of acute myocardial ischemia. The ECG in Acute Myocardial Infarction and Unstable Angina, written by Drs. Hein Wellens, Anton Gorgels and Pieter Doevendans, is an excellent reference for any cardiac electrophysiologist, cardiologist, internist or emergency room physician.

Quantitative Coronary Arteriography

Author: Johan H. C. Reiber,P.W. Serruys

Publisher: Springer Science & Business Media

ISBN: 9401137269

Category: Medical

Page: 396

View: 3749

In June 1989, a third conference concentrating on the progress in quantita tive coronary angiography and related techniques was held in Rotterdam, again very successful as the two preceding events in 1985 and 1987. Tech nical as well as clinical aspects of digital and digitized coronarography, morphometry, parametric imaging and functional quantification of the human coronary circulation were presented and discussed by prominent exponents of those groups who have been active in this particular field for many years. This book contains the chapters representing the lectures held by leading experts during the symposium that update the knowledge currently available, including most recent aspects in angioscopy and intravascular ultrasound imaging. It also includes a historical review on the development of angiogra phic techniques from the very early days on to our times given by one of the pioneers in heart catheterization and angiography, Dr. Kurt Amplatz. Those who had the chance to listen to his talk, will surely remember his impressive, humorous lecture as one of the highlights of this meeting.

Core Topics in Cardiac Anesthesia

Author: Jonathan H. Mackay,Joseph E. Arrowsmith

Publisher: Cambridge University Press

ISBN: 052119685X

Category: Medical

Page: 492

View: 9255

Since the publication of the first edition of Core Topics in Cardiac Anesthesia, the clinical landscape has undergone significant change. Recent developments include the increased use of electrophysiology, the resurgence of primary percutaneous intervention in acute coronary syndromes, the use of percutaneous devices in patients previously considered inoperable, and the withdrawal of aprotinin. Against this landscape, this invaluable resource has been fully updated. New chapters are dedicated to right heart valves, pulmonary vascular disease, cardiac tumours and cardiac trauma. All other chapters have been updated according to the latest international guidelines. Written and edited by an international author team with a wealth of expertise in all aspects of the perioperative care of cardiac patients, topics are presented in an easy to digest and a readily accessible manner. Core Topics in Cardiac Anesthesia, Second Edition is essential reading for residents and fellows in anesthesia and cardiac surgery and clinical perfusionists.

Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

Author: M. Morad,S. Ebashi,W. Trautwein,Yoshihisa Kurachi

Publisher: Springer Science & Business Media

ISBN: 9401139903

Category: Medical

Page: 602

View: 9357

Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

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