Search Results: excitation-contraction-coupling-and-cardiac-contractile-force-developments-in-cardiovascular-medicine

Excitation-Contraction Coupling and Cardiac Contractile Force

Author: Donald Bers

Publisher: Springer Science & Business Media

ISBN: 9401715122

Category: Medical

Page: 265

View: 1151

The main aim of this monograph is to provide an overview of calcium regulation in cardiac muscle cells, particularly with respect to excitation-contraction coupling and the control of cardiac contractile force. It is my hope that this book will be useful to students of the cardiovascular system and muscle at all different levels and in different disciplines (such as physiology, biochemistry, pharmacology and pathophysiology). I also hope that it will find use for those studying developmental, comparative and disease processes as well as more integrative phenomenon. I kept several goals in mind in writing this monograph. First, it should be easily readable. Second, I chose to include numerous illustrations and tables to help integrate results from numerous investigators in practical formats and also present key figures from important papers. Thus, this monograph may serve as a resource of information for people working in the areas described herein. Third, the presentation is a very personal one, and I have necessarily drawn extensively on my personal experience in this field over the past 15 years. This, I think, helps maintain a certain continuity of thought from chapter to chapter. Fourth, I have made serious attempts to make each chapter "up to date", despite the breadth of topics covered. I have also tried to be equitable in choosing references while not intending to be comprehensive or exhaustive. Neither of these aims can be perfectly matched, and I apologize to the many investigators whose papers I have not cited, but should have.

Excitation-Contraction Coupling and Cardiac Contractile Force

Author: D. M. Bers

Publisher: Springer Science & Business Media

ISBN: 9780792371571

Category: Medical

Page: 427

View: 6131

Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).

Heart Failure, Second Edition

Author: Marc Semigran,Jordan T. Shin

Publisher: CRC Press

ISBN: 1420077015

Category: Medical

Page: 500

View: 2054

Heart Failure, Second Edition has been updated to provide the latest advancements in heart failure research. Supplemented by more than 200 high-quality figures and illustrations, the book helps cardiologists and emergency care physicians quickly and accurately identify the cause and severity of a patient’s cardiac impairment. New topics in this edition include: Developments in mechanical and pharmacologic treatments Discoveries in developmental biology Up-and-coming imaging modalities Surgical options for mechanical circulatory support and cardiac transplantation Pharmacogenomics and gene-based and cell-based therapies Gene expression/recurrence in heart failure Changes in metabolic substrate utilization and pathways

The Journal of Experimental Biology

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Biology

Page: N.A

View: 3993

Drug Screening Methods

Author: Suresh Kumar Gupta,S. K. Gupta

Publisher: Anshan

ISBN: N.A

Category: Medical

Page: 501

View: 3716

Drug discovery and development is a challenging, expensive and time consuming field of research, requiring contributions from chemists, pharmacologists, toxicologists, clinicians, and practitioners. The ultimate goal is to generate a safe and biologically active drug which can stall, or even reverse, the pathological events that cause the disease condition. But in the search for the drug a host of tests and trials must be applied to evaluate the efficiency and safety of the newly developed molecule in the biological system. These trials or "screening methods" are critical. On their basis, the new molecule either becomes accepted for usage, or is discarded forever. Advances in drug research have forced the need for quicker, more automated screening methods, using molecular techniques applied in vitro, in vivo and in clinical systems. Researchers need to know the latest developments outside their own speciality. With this book, Professor Gupta has brought together in one coherent volume the most up to date developments of consolidated screening methods for biological systems. By paying attention to the practical techniques used in academia and the commercial pharmaceutical industry, "Drug Screening Methods" will enjoy a broad readership, serving both the professional community and the student of pharmacology.

Advances in Noninvasive Electrocardiographic Monitoring Techniques

Author: Hans-Heinrich Osterhues,Vinzenz Hombach,Arthur J. Moss

Publisher: Springer Science & Business Media

ISBN: 9780792362142

Category: Mathematics

Page: 493

View: 6725

An outgrowth of the Biennial International Congress on Holter and Noninvasive Electrocardiology held in Ulm, Germany, in May 1998. The 46 papers provide a snapshot of the field at the end of the century for clinical cardiologists and internists who use electrocardiographic procedures in managing their patients, researchers actively involved in the field, and students who will be working in it. They cover physiology and pathophysiology from genes and phenotypes to the autonomic nervous system, aspects investigated by different methods such as P-wave and QRS and T-wave alternans/repolarization, ischemic heart disease, ambulatory blood pressure monitoring and other methods, and non-linear dynamics and newer signal detection and analysis techniques.

Laboratory Animal Practitioner

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Laboratory animal technicions

Page: N.A

View: 7676

Myocardial Viability

Author: A.E. Iskandrian,Ernst E. van der Wall

Publisher: Springer Science & Business Media

ISBN: 9401140804

Category: Medical

Page: 244

View: 2427

AMI E. ISKANDRIAN & ERNST E. VAN DER WALL The first edition of this book was published in 1994. Since then important advances have occurred in the field of myocardial viability. This, coupled with increasing interest by the scientific community in the broader issues of its relevance to patient care, suggested to us the need to write the second edition. We are most fortunate to have the help of a distinguished group of experts who have helped shape the field; we appreciate their commitments and contributions. Almost all chapters have been radically modified. Chapter 1 deals with pathophysiology of myocardial hibernation and stunning; Chapter 2 with apoptosis; Chapter 3 with the role of positron emission tomography; Chapters 4 and 5 with the role of single photon emission computed tomography with thallium-201 and technetium agents, respectively; Chapter 6 with the role of SPECT fatty acid imaging; Chapter 7 with the role of SPECT FDG imaging; Chapter 8 with the role of cardiac catheterization angiography; Chapter 9 with the role of echocardiography; Chapter 10 with the role of magnetic resonance imaging; and Chapter 11 with clinical applications. Finally, Chapter 12 provides a short summary.

Stochastic models of intracellular calcium release and alternans

Author: Robert James Rovetti

Publisher: N.A

ISBN: N.A

Category: Science

Page: 278

View: 8173

Journal of Experimental Biology

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Biology

Page: N.A

View: 8364

Quantitative Coronary Arteriography

Author: Johan H. C. Reiber,P.W. Serruys

Publisher: Springer Science & Business Media

ISBN: 9401137269

Category: Medical

Page: 396

View: 5720

In June 1989, a third conference concentrating on the progress in quantita tive coronary angiography and related techniques was held in Rotterdam, again very successful as the two preceding events in 1985 and 1987. Tech nical as well as clinical aspects of digital and digitized coronarography, morphometry, parametric imaging and functional quantification of the human coronary circulation were presented and discussed by prominent exponents of those groups who have been active in this particular field for many years. This book contains the chapters representing the lectures held by leading experts during the symposium that update the knowledge currently available, including most recent aspects in angioscopy and intravascular ultrasound imaging. It also includes a historical review on the development of angiogra phic techniques from the very early days on to our times given by one of the pioneers in heart catheterization and angiography, Dr. Kurt Amplatz. Those who had the chance to listen to his talk, will surely remember his impressive, humorous lecture as one of the highlights of this meeting.

The ECG in Acute Myocardial Infarction and Unstable Angina

Author: Hein J.J. Wellens,Anton M. Gorgels,P.A.F.M. Doevendans,Pieter A. Doevendans

Publisher: Springer Science & Business Media

ISBN: 1402072147

Category: Medical

Page: 132

View: 9996

This volume, written by the leaders in the field, will provide a practical and comprehensive overview of the electrocardiogram (ECG). The ECG remains the most accessible and inexpensive diagnostic tool to evaluate the patient presenting with symptoms suggestive of acute myocardial ischemia. The ECG in Acute Myocardial Infarction and Unstable Angina, written by Drs. Hein Wellens, Anton Gorgels and Pieter Doevendans, is an excellent reference for any cardiac electrophysiologist, cardiologist, internist or emergency room physician.

Angiology in Practice

Author: A-M. Salmasi,A. Strano

Publisher: Springer Science & Business Media

ISBN: 9401154066

Category: Medical

Page: 530

View: 3250

Arterial and venous diseases are major causes of morbidity and mortality in most of the world, especially in the western hemisphere. Not only of interest to angiologists, these illnesses are also of concern to most physicians in various fields ranging from cardiology, general medicine and cardiovascular surgery to physiology, pathology and clinical pharmacology. Specialists in diabetes, hypertension and epidemiology find these illnesses as challenging in their own fields of interest due to the gross interrelation of these diseases with their specialities. This book of 35 chapters contains an up-to-date discussion of various arterial and venous illnesses presenting major clinical applications ranging from basic pathology, haemodynamics and haemorheology to clinical features and management. Special attention has also been paid to epidemiology and prevention, discussing all the issues concerned. A special section on vascular emergency has also been included, thereby extending its usefulness to physicians and surgeons working in accident and emergency units.

Animal models in cardiovascular research

Author: D.R. Gross

Publisher: Springer Science & Business Media

ISBN: 9401707308

Category: Medical

Page: 501

View: 1783

Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the first edition of this textbook. This completely revised and updated text provides information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation have been changed to make the text more easy to read and use. An introductory chapter offers general principles of animal selection, pre and post-operative care, preanesthesia, chemical restraint, analgesia, and the recognition of pain. The number of references cited has been almost doubled over the previous text and the chapter tabulating normal cardiovascular parameters from intact, awake animals, of those species commonly used in research, has been greatly expanded. Other chapters providing comprehensive data on the cardiovascular effects of opioids, tranquilizers, anesthetic agents and other drugs commonly used in cardiovascular research have been expanded with special emphasis on species variability to drug effects. The chapters on both naturally occurring and iatrogenic models of cardiovascular disease have also been expanded and updated.

The Arterial System in Hypertension

Author: Michel Emile Safar,M.F. O'Rourke

Publisher: Springer Science & Business Media

ISBN: 9401109001

Category: Medical

Page: 240

View: 5453

MICHEL E. SAFAR and MICHAEL F. O'ROURKE One of the principal problems of hypertension is the precise definition of blood pressure as a cardiovascular risk factor. Clinicians indicate peak systolic pressure and end diastolic pressure in the brachial artery as the principal criteria for blood pressure measurement. Consequently, these values are as indicators for clinical management and therapeutic adjustment. This used methodology, based on indirect blood pressure measurements at the site of the brachial artery relates only to the highest and lowest pressure in that vessel, and does not give any information of the blood pressure curve itself; this carries more information than peak systolic pressure and end diastolic pressure. As a first step in better analysis of the blood pressure curve, research workers in experimental hypertension defined in addition to peak systolic pressure and end diastolic, another blood pressure value, mean arterial pressure, i. e. the average pressure throughout the cardiac cycle, and about which pressure fluctuates. This is the pressure recorded by Hales [1] and by Poiseuille [2] in their pioneering studies. By application of Poiseuille's Law, this definition of mean arterial pressure led to the concept that increased mean arterial pressure (and therefore hypertension) was related, at any given value of cardiac output, to an increase in vascular resistance, i. e. to a reduc tion in the caliber of the small arteries.

Myocardial viability

Detection and clinical relevance

Author: A.S. Iskandrian,Ernst E. van der Wall

Publisher: Springer Science & Business Media

ISBN: 9401111707

Category: Medical

Page: 203

View: 6149

In the past few years it has become clear that left ventricular dysfunction, even of severe degree, may be reversible after coronary revascularization in some patients. As a result, myocardial viability has captured the imagination of researchers and clinicians seeking to unravel the cellular and subcellular mechanisms and define appropriate diagnostic modalities. These diagnostic modalities include: cardiac catheterization, positron-emission tomography, magnetic resonance imaging, two-dimensional echocardiography and single-photon imaging. This book, for the first time, brings together a diverse array of information in a comprehensive and concise fashion using a template of ten chapters written by experts in the field. It will be required reading for cardiologists, radiologists, nuclear medicine specialists, cardiac surgeons, anesthesiologists, internists and basic researchers and their trainees who are involved in the management of patients with coronary artery disease in whom myocardial viability is a clinically relevant issue.

Nuclear Cardiology in Everyday Practice

Author: J. Candell-Riera,D. Ortega-Alcalde

Publisher: Springer Science & Business Media

ISBN: 9401119848

Category: Medical

Page: 401

View: 7412

The most salient feature of the infor last four chapters of the book evaluate the mation provided by nuclear medicine is its information from an analytical and pathophysiological and functional charac statistical point of view. This approach is ter. For adequate experimental or clinical required for correct decision-making. interpretation, such information should This book is therefore the result of necessarily be interpreted alongside the accumulated experience in nuclear cardiology views of the clinical cardiologist, who is with the invaluable cooperation of medical able to apply it to the individual patient. statisticians. It is directed to physicians This approach, which is routine in every with an interest in nuclear cardiology, to day clinical practice, reaches its plenitude nuclear medicine specialists wishing to when the whole process is completed and learn the uses and limitations of these an intimate cooperation is established procedures in everyday clinical cardiology, between the nuclear medicine specialist and to cardiologists who feel the need to and the clinical cardiologist. In such understand the rationale and methodology instances, each one of these professionals of the studies which benefit their patients. understands the needs, limits and possi We understand that the ultimate reason bilities of the other. for any scientific book is the transmission The present book is the fruit of such of knowledge, and we are fully conscious cooperation. In our hospital, an efficient of the enthusiasm of the authors of the nuclear cardiology team has been made up present text to achieve that aim.

Molecular Cardiology for the Cardiologists

Author: Bernard Swynghedauw

Publisher: Springer Science & Business Media

ISBN: 1461520193

Category: Medical

Page: 250

View: 4027

Molecular Cardiology for the Cardiologist provides a short, easily readable summary of what the new biology brings to cardiology. With this in mind, special efforts have been made to present many comprehensive schemes and drawings, as well as teaching tables. The five parts of the book provide a general introduction to the new language of biology; the normal structure of the heart and blood vessels; the physiopathology and the new therapeutic avenues that have been opened up by the new biology. A concise summary of the keys that assist the cardiologist or student who seeks to learn and read more about this field. Provides practical examples to illustrate the clinical interest of the new approach.

Cardiovascular Imaging

Author: Johan H. C. Reiber,Ernst E. van der Wall

Publisher: Springer Science & Business Media

ISBN: 9400902913

Category: Medical

Page: 578

View: 8701

In the past, coronary arteriography was the only modality available to provide high quality images of the coronary anatomy. Quantitative coronary arteriography (QCA) was developed, implemented, validated and extensively applied to obtain accurate and reproducible data about coronary morphology and the functional significance of coronary obstructions. Over the last few years extensive basic technological research supported by clinical investigations has created competing modalities to visualize coronary morphology and the associated perfusion of the myocardial muscle. Currently, the following modalities are available: X-ray coronary arteriography, intracoronary ultrasound, contrast- and stress-echocardiography, angioscopy, nuclear cardiology, magnetic resonance imaging, and cine and spiral CT imaging. For all these imaging modalities, the application of dedicated quantitative analytical software packages enables the evaluation of the imaging studies in a more accurate, reliable, and reproducible manner. These extensions and achievements have resulted in improved diagnostics and subsequently in improved patient care. Particularly in patients with ischaemic heart disease, major progress has been made to detect coronary artery disease in an early phase of the disease process, to follow the atherosclerotic changes in the coronary arteries, to establish the functional and metabolic consequences of the luminal obstructions, and accurately to assess the results of interventional therapy. Aside from all these high-tech developments in cardiac imaging techniques, the transition from the analogue to the digital world has been going on for some time now. For the future, it has been predicted that the CD-R will be the exchange medium for cardiac images and DICOM-3 the standard file format. This has been a major achievement in the field of standardization activities. Since these developments will have a major impact on the way images will be stored, reviewed and exchanged in the near future, an important part of this book has been dedicated to DICOM and the filmless catheterization laboratory. Cardiovascular Imaging will assist cardiologists, radiologists, nuclear medicine physicians, image processing specialists, physicists, basic scientists, and fellows in training for these specialties to understand the most recent achievements in cardiac imaging techniques and their impact on cardiovascular medicine.

Lipid-Lowering Therapy and Progression of Coronary Atherosclerosis

Author: A.V. Bruschke,Johan H. C. Reiber,K.J. Lie,Hein J.J. Wellens

Publisher: Springer Science & Business Media

ISBN: 9400901437

Category: Medical

Page: 240

View: 6659

A unique overview of all major angiographic lipid intervention trials, presented by their principal investigators. Basic mechanisms and methodological aspects, including biochemical as well as angiographic aspects, are discussed by experts in these fields. A careful comparison of all available data permits an analysis to be made of what may currently be considered proved, which aspects merit further investigation, and which hypotheses should be rejected. Audience: Clinicians involved in the practice of lipid lowering and investigators involved in lipid-lowering clinical trials. Scientists involved in other areas of lipid research and investigators conducting coronary angiographic trials designed to study the influence of different interventions will find a wealth of information and practical guidelines in this book.

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