Search Results: organic-chemistry-of-enzyme-catalyzed-reactions-revised-edition-second-edition

Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

Author: Richard B. Silverman

Publisher: Elsevier

ISBN: 0080513360

Category: Science

Page: 800

View: 6275

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

The Organic Chemistry of Drug Design and Drug Action

Author: Richard B. Silverman,Mark W. Holladay

Publisher: Academic Press

ISBN: 0123820316

Category: Medical

Page: 536

View: 4100

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

Principles of Enzymology for the Food Sciences, Second Edition,

Author: John R. Whitaker

Publisher: CRC Press

ISBN: 9780824791483

Category: Technology & Engineering

Page: 648

View: 7063

This second edition explains the fundamentals of enzymology and describes the role of enzymes in food, agricultural and health sciences. Among other topics, it provides new methods for protein determination and purification; examines the novel concept of hysteresis; and furnishes new information on proteases, oxidases, polyphenol oxidases, lipoxygenases and the enzymology of biotechnology.

Food Additives, Second Edition Revised And Expanded

Author: N.A

Publisher: Routledge

ISBN: 1135569479

Category:

Page: N.A

View: 5155

Laboratory Techniques in Electroanalytical Chemistry, Second Edition, Revised and Expanded

Author: Peter Kissinger,William R. Heineman

Publisher: CRC Press

ISBN: 9780824794453

Category: Science

Page: 1008

View: 8825

This volume provides a practical, intuitive approach to electroanalytical chemistry, presenting fundamental concepts and experimental techniques without the use of technical jargon or unnecessarily extensive mathematics. This edition offers new material on ways of preparing and using microelectrodes, the processes that govern the voltammetric behavior of microelectrodes, methods for characterizing chemically modified electrodes, electrochemical studies at reduced temperatures, and more. The authors cover such topics as analog instrumentation, overcoming solution resistance with stability and grace in potentiostatic circuits, conductivity and conductometry, electrochemical cells, carbon electrodes, film electrodes, microelectrodes, chemically modified electrodes, mercury electrodes, and solvents and supporting electrolytes.

Catalytic Asymmetric Synthesis

Author: Iwao Ojima

Publisher: John Wiley & Sons

ISBN: 1118678443

Category: Science

Page: 768

View: 1667

Praise for the previous editions "An excellent text . . . will no doubt provide the benchmark for comparative works for many years." —Journal of the American Chemical Society "An excellent state-of-the-art compilation of catalytic asymmetric chemistry . . . should be included in any chemistry reference collection." —Choice "This is a tremendous resource and an excellent read. I recommend immediate purchase." —Perkin Transactions Since this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields—from medicine to materials science. Catalytic Asymmetric Synthesis, Third Edition addresses these rapid changes through contributions from highly recognized world leaders in the field. This seminal text presents detailed accounts of the most important catalytic asymmetric reactions known today, and discusses recent advances and essential information on the initial development of certain processes. An excellent working resource for academic researchers and industrial chemists alike, the Third Edition features: Six entirely new chapters focusing on novel approaches to catalytic asymmetric synthesis including non-conventional media/conditions, organocatalysis, chiral Lewis and Bronsted acids, CH activation, carbon-heteroatom bond-forming reactions, and enzyme-catalyzed asymmetric synthesis A new section focusing on the important new reaction, asymmetric metathesis, in carbon-carbon bond-forming reactions Updated chapters on hydrogenation, carbon-carbon bond-forming reactions, hydrosilylations, carbonylations, oxidations, amplifications and autocatalysis, and polymerization reactions Retaining the best of its predecessors but now thoroughly up to date, Catalytic Asymmetric Synthesis, Third Edition serves as an excellent desktop reference and text for researchers and students from the upper-level undergraduates through experienced professionals in industry or academia.

Enzymes

A Practical Introduction to Structure, Mechanism, and Data Analysis

Author: Robert A. Copeland

Publisher: John Wiley & Sons

ISBN: 0471461857

Category: Science

Page: 416

View: 3763

Fully updated and expanded-a solid foundation for understanding experimental enzymology. This practical, up-to-date survey is designed for a broad spectrum of biological and chemical scientists who are beginning to delve into modern enzymology. Enzymes, Second Edition explains the structural complexities of proteins and enzymes and the mechanisms by which enzymes perform their catalytic functions. The book provides illustrative examples from the contemporary literature to guide the reader through concepts and data analysis procedures. Clear, well-written descriptions simplify the complex mathematical treatment of enzyme kinetic data, and numerous citations at the end of each chapter enable the reader to access the primary literature and more in-depth treatments of specific topics. This Second Edition of Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis features refined and expanded coverage of many concepts, while retaining the introductory nature of the book. Important new features include: A new chapter on protein-ligand binding equilibria Expanded coverage of chemical mechanisms in enzyme catalysis and experimental measurements of enzyme activity Updated and refined discussions of enzyme inhibitors and multiple substrate reactions Coverage of current practical applications to the study of enzymology Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.

Microreactors in Organic Chemistry and Catalysis

Author: Thomas Wirth

Publisher: John Wiley & Sons

ISBN: 3527659749

Category: Science

Page: 478

View: 5861

For the second edition of 'Microreactors in Organic Chemistry and Catalysis' all chapters have been revised and updated to reflect the latest developments in this rapidly developing field. This new edition has 60% more content, and it remains a comprehensive publication covering most aspects of the topic. The use of microreactors in homogeneous, heterogeneous as well as biphasic reactions is covered in the main part of the book, together with catalytic, bioorganic and automation approaches. The initial chapters also provide a solid physical chemistry background on fluidics in microdevices. Finally, a chapter on industrial applications and developments covers recent progress in process chemistry. An excellent reference for beginners and experts alike.

The Regulation of Membrane Lipid Metabolism, Second Edition

Author: Guy A. Thompson, Jr.

Publisher: CRC Press

ISBN: 9780849345616

Category: Medical

Page: 240

View: 2058

This book provides a concise description of the metabolic pathways by which lipids of animal and plant membranes are formed. The book emphasizes modulation of these pathways by hormones, diet, environmental stress, and other factors. This new edition is extensively revised, containing new material on topics such as lipid-mediated signal transduction and lipid-induced protein translocation. The new edition also features an entirely new chapter on lipids covalently bound to proteins. The book is excellent for all researchers and students interested in membrane lipid metabolism.

Essential Organic Chemistry

Author: Paula Yurkanis Bruice

Publisher: Pearson College Division

ISBN: 9780321596956

Category: Science

Page: 567

View: 3970

Designed for a one-term course, this organic chemistry helps students see organic chemistry as an interesting and exciting science and to give them an opportunity to develop critical thinking skills.

Organic Chemistry: With Biological Applications

Author: John E. McMurry

Publisher: Cengage Learning

ISBN: 0495391441

Category: Science

Page: 1152

View: 3170

Renowned for its student-friendly writing style and fresh perspective, this fully updated Second Edition of John McMurry's ORGANIC CHEMISTRY WITH BIOLOGICAL APPLICATIONS provides full coverage of the foundations of organic chemistry enhanced by biological examples throughout. Based on user feedback, McMurry continues to discuss the organic chemistry of biological pathways and now adds two dozen additional organic chemistry topics, as well as new problems, new illustrations, and new essays. Media integration with OWL for Organic Chemistry, a customizable online learning system and assessment tool, reduces faculty workload, facilitates instruction, and helps students master concepts through tutorials, simulations, and algorithmically generated homework questions. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Reaction Kinetics and Reactor Design, Second Edition

Author: John B. Butt

Publisher: CRC Press

ISBN: 9780824777227

Category: Science

Page: 752

View: 3327

This text combines a description of the origin and use of fundamental chemical kinetics through an assessment of realistic reactor problems with an expanded discussion of kinetics and its relation to chemical thermodynamics. It provides exercises, open-ended situations drawing on creative thinking, and worked-out examples. A solutions manual is also available to instructors.

Textbook of Drug Design and Discovery, Third Edition

Author: Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen

Publisher: CRC Press

ISBN: 9780415282888

Category: Medical

Page: 592

View: 453

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Ribozymes and RNA Catalysis

Author: David Malcolm James Lilley,Fritz Eckstein

Publisher: Royal Society of Chemistry

ISBN: 0854042539

Category: Science

Page: 318

View: 3352

The emphasis of this book concerns the origins of catalysis in RNA and is well suited for undergraduates, postgraduates and researchers in catalytic chemistry.

New Trends in Enzyme Catalysis and Biomimetic Chemical Reactions

Author: Gertz I. Likhtenshtein

Publisher: Springer Science & Business Media

ISBN: 0306481103

Category: Science

Page: 230

View: 1987

Nutritional Toxicology, Second Edition

Author: Frank N. Kotsonis,Maureen A. Mackey

Publisher: CRC Press

ISBN: 0415248655

Category: Medical

Page: 472

View: 3157

Nutrients are gaining recognition for their role in protecting against the toxic effects of free radicals, alcohol and other substances. At the same time, advances in food technology, the appearance of novel foods and new ingredients have generated new toxicological issues and forced health and safety professionals to develop new and more reliable methods to assess their impact on our health. These issues are at the heart of the second edition of Nutritional Toxicology. The book discusses the role of nutrients in protecting the body against toxicants. It explores the overall importance of the metabolism of xenobiotics and antioxidant nutrients in their increasingly important role in protecting against oxidative damage generated by free radicals. The book also discusses components of the diet that can influence metabolism of drugs, how alcohol consumption affects nutritional status, and conversely, how nutritional status affects alcohol metabolism. The effect of age on the body's ability to metabolize drugs and toxicants is discussed in detail.

Immobilization of Enzymes and Cells

Author: Jose M. Guisan

Publisher: Springer Science & Business Media

ISBN: 1597450537

Category: Science

Page: 449

View: 3818

The continuing rapid progress in work designed to improve the functional properties of enzymes and cells as industrial catalysts has led to this revised, updated, and expanded new edition of the warmly received initial edition of Immobilization of Enzymes and Cells. This long-awaited second edition contains new and simplified protocols useful for industrial applications, novel techniques that will prove useful now or in the near future, and protocols for the preparation of immobilized derivatives suitable for a wide variety of nonconventional reaction media. The authors also offer tools for the development of new immobilization techniques, methods for preparing immobilized derivatives for therapeutic and industrial use, and new chemical reactors designed to overcome the limitations of immobilized derivatives. The emphasis is on improving enzyme and cell properties via very simple immobilization protocols, along with the development of new and better methods. The protocols follow the successful Methods in Biotechnology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Innovative and highly practical, Immobilization of Enzymes and Cells, Second Edition, affords biochemists, biotechnologists, and biochemical engineers a practical review of all the latest methods and tools-as well as optimized conventional techniques-needed to carry out successful research involving immobilizing enzymes and cells.

Drug Stereochemistry

Analytical Methods and Pharmacology, Second Edition,

Author: Irving Wainer

Publisher: CRC Press

ISBN: 9780824788193

Category: Science

Page: 436

View: 9453

Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.

Introduction to Enzyme and Coenzyme Chemistry

Author: T. D. H. Bugg

Publisher: John Wiley & Sons

ISBN: 1118348990

Category: Science

Page: 280

View: 6602

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

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