Search Results: the-organic-chemistry-of-drug-design-and-drug-action-third-edition

The Organic Chemistry of Drug Design and Drug Action

Author: Richard B. Silverman,Mark W. Holladay

Publisher: Academic Press

ISBN: 0123820316

Category: Medical

Page: 536

View: 2665

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

Analytik

Daten, Formeln, Übungsaufgaben

Author: N.A

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 3110423588

Category: Mathematics

Page: 427

View: 2686

Küster and Thiel’s seminal textbook, formerly titled Computational Tables for Chemical Analytics, is a comprehensive compilation of the most important methods and data of analytical chemistry and an essential reference work for laboratory work. In addition to numerous tables, the reader also will find many explanations and examples, including detailed descriptions of calculations, which greatly simplify the use of the work.

Textbook of Drug Design and Discovery, Third Edition

Author: Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen

Publisher: CRC Press

ISBN: 9780415282888

Category: Medical

Page: 592

View: 7462

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Drug Design and Action

Author: Joaquín M. Campos Rosa,M. Encarnación Camacho Quesada

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 3110528487

Category: Science

Page: 186

View: 4994

This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents.

Strukturaufklärung mit moderner NMR-Spektroskopie

Ein Übungsbuch

Author: H. Duddeck,W. Dietrich

Publisher: Springer-Verlag

ISBN: 3642977766

Category: Science

Page: 197

View: 7098

Medicinal Chemistry of Anticancer Drugs

Author: Carmen Avendano,J. Carlos Menendez

Publisher: Elsevier

ISBN: 9780080559629

Category: Medical

Page: 400

View: 2104

Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Biochemie antimikrobieller Wirkstoffe

Author: Trevor J. Franklin,George A. Snow

Publisher: Springer-Verlag

ISBN: 3642654851

Category: Science

Page: 186

View: 8761

Biopsychologie

Author: John P. J. Pinel

Publisher: N.A

ISBN: 9783827372178

Category: Physiologische Psychologie - Lehrbuch

Page: 677

View: 7016

Wirkstoffdesign

Entwurf und Wirkung von Arzneistoffen

Author: Gerhard Klebe

Publisher: Springer-Verlag

ISBN: 3827422132

Category: Medical

Page: 637

View: 738

Dieses für den deutschen Raum einzigartige Lehrbuch richtet sich an Studenten der Pharmazie, Chemie und Biowissenschaften, aber auch an Quereinsteiger in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Die zweite Auflage ist komplett überarbeitet. Zahlreiche aktuelle Entwicklungen vor allem im methodischen Bereich sind zum Teil in neuen Kapiteln aufgegriffen, viele Fallbeispiele machen die Theorien und Verfahren anschaulich und nachvollziehbar. Der Bogen spannt sich von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung über Strukturbestimmungsmethoden, Modelling, Moleküldynamik und QSAR-Methoden bis zum struktur- und computergestützten Design. Insgesamt legt das Buch besonderen Wert auf die räumliche Struktur der interagierenden Moleküle und erklärt, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Die beiliegende DVD mit interaktiven Molekülmodellen dient dem Ziel, dem Lernenden einen leichten Zugang zum räumlichen Verständnis der molekularen Strukturen und Interaktionen zu geben.

Molekülorbitale und Reaktionen organischer Verbindungen

Author: Ian Fleming

Publisher: John Wiley & Sons

ISBN: 3527330690

Category: Chemical bonds

Page: 399

View: 7789

Der lang erwartete Nachfolger des Klassikers "Grenzorbitale und Reaktionen organischer Verbindungen". Die Molekülorbitalheorie wird einfach, ohne komplizierte mathematische Formeln und mit vielen illustrativen Beispielen erklärt.

Medicinal Chemistry

A Molecular and Biochemical Approach

Author: Thomas Nogrady,Donald F. Weaver

Publisher: Oxford University Press

ISBN: 9780195104554

Category: Medical

Page: 649

View: 2416

Fully updated, this textbook takes a receptor-based, target-centred approach, presenting concepts central to the study of drug action in a logical, mechanistic way, grounded on molecular & biochemical principles.

Taschenatlas Pharmakologie

Author: Lutz Hein,Heinz Lüllmann,Klaus Mohr

Publisher: Georg Thieme Verlag

ISBN: 3131516577

Category: Medical

Page: 416

View: 5359

Wirkt sofort! Dieser Taschenatlas hilft. Beschwerden der Verwirrung und Überforderung werden sofort gemildert und weichen dem Gefühl des Verstehens und Begreifens. Die Wirkstoffe Visualisierung und Kompaktheit sind in großen Mengen aktiv. - Über 170 brillante Infografiken illustrieren die Pharmakologie und erleichtern dir den Zugang zu pharmakologischen Sachverhalten. Die kompakten Lerneinheiten eignen sich als Ergänzung zu einem Lehrbuch, zum Vertiefen und Wiederholen. Alle relevanten Informationen zu Wirkstoffgruppen kannst du rasch und gut verständlich nachlesen. Das sinnvolle arzneimitteltherapeutische Vorgehen bei wichtigen Erkrankungen kompakt und auf dem aktuellen Stand. Arzneimittel-Konvertierungslisten helfen dir auf der Suche nach dem Wirkstoff- oder Handelsnamen. Dank Daumenregister und Farbleitsystem kannst du dich schnell orientieren. Du verstehst Zusammenhänge und schaust über den ein oder anderen Tellerrand.

Enzyme Kinetics: Catalysis and Control

A Reference of Theory and Best-Practice Methods

Author: Daniel L. Purich

Publisher: Elsevier

ISBN: 0123809258

Category: Science

Page: 920

View: 6804

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Calcium-Antagonisten

Eine kritische Analyse

Author: Helmut Lydtin,Peter Trenkwalder

Publisher: Springer-Verlag

ISBN: 3662061996

Category: Medical

Page: 259

View: 1962

Calcium-Antagonisten werden heute weltweit in der Therapie von Erkrankungen des Herz-Kreislauf-Systems eingesetzt. Bei zahlreichen weiteren Indikationen - aus der Neurologie über die Gynäkologie bis zur Urologie und Onkologie - wird ihr Einsatz diskutiert. Parallel zu dieser Entwicklung hat das Konzept des Calcium-Antagonismus fast alle Bereiche der Physiologie, Pathophysiologie und Pharmakologie befruchtet. Die Literatur über Calcium-Antagonisten ist heute für den praktisch tätigen Arzt kaum mehr überschaubar. Das vorliegende Buch wertet kritisch und objektiv das umfangreiche Literaturangebot und informiert über den praktischen Umgang mit allen bisher genauer untersuchten Calcium-Antagonisten. Ausgehend von den physiologischen Grundlagen werden die allgemeine und spezielle Pharmakologie der Calcium-Antagonisten sowie ihre Wirkung auf die verschiedenen Organsysteme dargestellt. Im Mittelpunkt steht der therapeutische Einsatz der Calcium-Antagonisten aufgrund klar definierter Therapieziele mit Angaben zum praktischen Vorgehen (Dosierungen, Nebenwirkungen, Interaktionen, therapeutische Alternativen).

Papyros Ebers

Das älteste Buch über Heilkunde

Author: H. Joachim

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 3111521761

Category: History

Page: 234

View: 4970

Molekulare Zellbiologie

Author: Arnold Berk,David Baltimore,Harvey Lodish,James Darnell,Paul Matsudaira,S. Lawrence Zipursky

Publisher: Walter de Gruyter

ISBN: 3110810573

Category: Science

Page: 1491

View: 386

Enzyklopädie der technischen Chemie

Author: Fritz Ullmann

Publisher: N.A

ISBN: N.A

Category: Chemistry, Technical

Page: N.A

View: 2609

Medicinal Chemistry—III

Main Lectures Presented at the Third International Symposium on Medicinal Chemistry

Author: P. Pratesi

Publisher: Elsevier

ISBN: 1483284743

Category: Medical

Page: 176

View: 1741

Medicinal Chemistry–III provides information pertinent to the fundamental aspects of medicinal chemistry. This book discusses the mechanism of action of drugs at the molecular level. Organized into eight chapters, this book begins with an overview of the systems for protein biosynthesis that are classified according to their mechanism and the selective action of drugs on their reactions. This text then examines the key structure in the biosynthesis of the peptidoglycans of bacterial cell walls. Other chapters consider the enzymes that transcribe DNA synthesizing RNA, which have structural differences in eukaryotic and prokaryotic cells. This book discusses as well the concepts for drug screening as they have been emerged from neurochemical research. The final chapter deals with the significance of molecular orbital theory in the hands of the biologist or chemists, which lies in its ability to derive information regarding the properties of molecules. This book is a valuable resource for organic, physical, and biological chemists.

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