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Cardiac Dysfunction in Chronic Uremia

Author: Patrick Parfrey

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 318

View: 115

Cardiac disease is the major cause of death in dialysis patients, accounting for over one third of deaths. This book focuses on myocardial function and dysfunction in chronic uremia. It is aimed at practicing and training nephrologists, cardiologists, and internists, and at research workers in the field. We have tried to produce an up-to-date, in-depth review of the subject by inviting experts in clinical epidemiology, pathophysiology, and thera peutics to write the 18 chapters. The book is divided into three sections. The first section comprises five chapters that provide an overview of the burden of illness associated with cardiac disease in end-stage renal disease and a review of clinical epidemi ological aspects of various cardiac diseases that occur in renal patients. The second section discusses abnormalities of left ventricular contractility and mass, and the factors that predispose to both systolic and diastolic disorders. The importance of hypertension, anemia, hyperparathyroidism, hyper lipidemia, and diabetes mellitus in predisposing to these abnormalities is reviewed splendidly by researchers active in these areas. The final section concentrates on therapeutics. Data and opinion on management of congestive heart failure, cardiomyopathy, coronary artery disease, hypertension, and arrhythmias are provided. In editing this book, we have reviewed an extensive literature, but un fortunately we have become more aware that substantial gaps in our knowl edge exist. Insufficient high-quality clinical research has been undertaken xiii xiv Preface regarding the various cardiac diseases that occur in end-stage renal disease.

Cardiac Dysfunction in Chronic Uremia

Author: Patrick S. Parfrey

Publisher: Springer

ISBN:

Category: Medical

Page: 318

View: 374

Cardiac disease is the major cause of death in dialysis patients, accounting for over one third of deaths. This book focuses on myocardial function and dysfunction in chronic uremia. It is aimed at practicing and training nephrologists, cardiologists, and internists, and at research workers in the field. We have tried to produce an up-to-date, in-depth review of the subject by inviting experts in clinical epidemiology, pathophysiology, and thera peutics to write the 18 chapters. The book is divided into three sections. The first section comprises five chapters that provide an overview of the burden of illness associated with cardiac disease in end-stage renal disease and a review of clinical epidemi ological aspects of various cardiac diseases that occur in renal patients. The second section discusses abnormalities of left ventricular contractility and mass, and the factors that predispose to both systolic and diastolic disorders. The importance of hypertension, anemia, hyperparathyroidism, hyper lipidemia, and diabetes mellitus in predisposing to these abnormalities is reviewed splendidly by researchers active in these areas. The final section concentrates on therapeutics. Data and opinion on management of congestive heart failure, cardiomyopathy, coronary artery disease, hypertension, and arrhythmias are provided. In editing this book, we have reviewed an extensive literature, but un fortunately we have become more aware that substantial gaps in our knowl edge exist. Insufficient high-quality clinical research has been undertaken xiii xiv Preface regarding the various cardiac diseases that occur in end-stage renal disease.

Miscellaneous Catalogues of Autographs.

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Cardiorenal Syndrome

Mechanisms, Risk and Treatment

Author: Adel E. Berbari

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 396

View: 421

Chronic kidney disease with a worldwide prevalence of 10% in the general population is emerging as a major public health priority. Renal dysfunction is associated with a high risk for cardiovascular complications. The relationship between renal insufficiency and cardiovascular disease, termed the cardiorenal syndrome exists whether impairment of renal function is a consequence of primary renal parenchymal disease or primary heart disease. Several pathophysiologic mechanisms have been postulated to explain the relationship between renal dysfunction and cardiovascular disease. Recent studies indicate an integrated response of the vascular smooth muscles and glomerular mesangial cells to traditional and uremia related cardiovascular risk factors. Traditional risk factors can incite renal impairment and cardiac damage. As renal function deteriorates, uremia-related risk factors play an increasing role both in reduction in glomerular filtration rate and cardiovascular damage. Several uremia related factors such as uncontrolled hypertension, disturbed glucose insulin metabolism, microalbuminuria, phosphate retention, secondary hyperparathyroidism, myocardial and vascular calcification, hypertensive-uremic cardiomyopathy, inflammation, oxidant injury, and neurohormonal dysregulation have been implicated in the pathogenesis of the cardiorenal syndrome. Recent data suggest that management of the cardiorenal syndrome requires aggressive control of traditional risk factors as well novel approaches to prevent or reverse uremia –related processes. This book provides a comprehensive update analysis of our current understanding of the cardiorenal syndrome including epidemiology, pathophysiologic mechanisms, and therapeutic approaches.

Replacement of Renal Function by Dialysis

Author: Walter H. Hörl

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 1604

View: 355

The leading Textbook on the subject. A completely rewritten and up-to-date fifth edition, based upon the highly respected fourth edition, edited by C. Jacobs, C.M. Kjellstrand, K.M. Koch and J.F. Winchester. This new edition is truly global in scope and features the contributions of the top experts from around the world.

Cardiorenal Syndrome

Mechanisms, Risk and Treatment

Author: Adel E. Berbari

Publisher: Springer

ISBN:

Category: Medical

Page: 396

View: 643

Chronic kidney disease with a worldwide prevalence of 10% in the general population is emerging as a major public health priority. Renal dysfunction is associated with a high risk for cardiovascular complications. The relationship between renal insufficiency and cardiovascular disease, termed the cardiorenal syndrome exists whether impairment of renal function is a consequence of primary renal parenchymal disease or primary heart disease. Several pathophysiologic mechanisms have been postulated to explain the relationship between renal dysfunction and cardiovascular disease. Recent studies indicate an integrated response of the vascular smooth muscles and glomerular mesangial cells to traditional and uremia related cardiovascular risk factors. Traditional risk factors can incite renal impairment and cardiac damage. As renal function deteriorates, uremia-related risk factors play an increasing role both in reduction in glomerular filtration rate and cardiovascular damage. Several uremia related factors such as uncontrolled hypertension, disturbed glucose insulin metabolism, microalbuminuria, phosphate retention, secondary hyperparathyroidism, myocardial and vascular calcification, hypertensive-uremic cardiomyopathy, inflammation, oxidant injury, and neurohormonal dysregulation have been implicated in the pathogenesis of the cardiorenal syndrome. Recent data suggest that management of the cardiorenal syndrome requires aggressive control of traditional risk factors as well novel approaches to prevent or reverse uremia –related processes. This book provides a comprehensive update analysis of our current understanding of the cardiorenal syndrome including epidemiology, pathophysiologic mechanisms, and therapeutic approaches.

Principles and Practice of Dialysis

Author: William L. Henrich

Publisher: Lippincott Williams & Wilkins

ISBN:

Category: Medical

Page: 752

View: 599

This book is an evidence-based review of the practical challenges of dealing with patients receiving dialysis. The first section covers technical and procedural considerations such as choosing the hemodialysis membrane and choosing the best dialysis option. The second section covers clinical considerations such as infection and the treatment of specific renal disease complications. The book includes numerous illustrations and tables and drug charts for dialysis patients. This edition's current outcomes chapter has been expanded to include patient depression and improving quality of care. New chapters cover dialysis in the ICU, valvular heart disease, and pre-emptive renal transplantation.

Replacement of Renal Function by Dialysis

Author: C. Jacobs

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 1536

View: 724

... About previous editions ... `The standard reference book for the artificial kidney world.' JAMA `The aim of the authors - to produce a standard text for nephrologists and those with an interest in today's treatment of renal failure - is fully achieved.' Urological Research `A superb book ... the detail and depth of discussions are unequalled in any current nephrology text.' Mayo Clinic Proceedings.

Uremic Toxins and Organ Failure

Author: Hideyuki Saito

Publisher: Springer

ISBN:

Category: Medical

Page: 180

View: 764

This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.

Complications of Dialysis

Author: Norbert Lameire

Publisher: CRC Press

ISBN:

Category: Medical

Page: 888

View: 438

Responding to the rising number of ESRD patients and the increasing importance of dialysis care and management, Complications of Dialysis provides a comprehensive, multidisciplinary perspective on the latest therapy options-addressing complications that may arise from dialysis and utilizing the patient-, technique-, and relationship-oriented approa

Current Catalog

Author: National Library of Medicine (U.S.)

Publisher:

ISBN:

Category: Medicine

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View: 258

First multi-year cumulation covers six years: 1965-70.

The International Journal of Pediatric Nephrology

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Regional Anesthesia and Analgesia

Author: David Lee Brown

Publisher: Saunders

ISBN:

Category: Medical

Page: 749

View: 894

This comprehensive, clinically oriented text can serve as either a stand-alone reference or as a companion to the ATLAS. Sections cover the development of regional anesthesia; basic science; induction of regional anesthesia; side effects, complications, and concurrent medical problems; and clinical applications. Each chapter features excellent illustrations and clinical pearls. User-friendly organization makes information easy to find! Basic science information is segregated from clinical chapters - making both background and clinical details easier to find. This section provides a foundation in the anatomic, physiologic, and pharmacologic considerations essential to performing regional block techniques successfully. Clinical pearls are highlighted! In each clinically oriented chapter, leading experts provide an in-depth summary of their subject as well as detailed insights into the nuances of clinical practice based on years of practical experience. Cross-referenced to the Atlas of Regional Anesthesia! Readers can use this complete resource as a stand-alone clinical reference or in tandem with Dr. Brown's Atlas of Regional Anesthesia. Either way, readers gain the 'how-to' advice that makes it easier to put the principles into practice. Superb art program! Features more than 465 informative line drawings and photographs that clarify and accentuate essential concepts, skillsand techniques. These illustrations are exclusive to Regional Anesthesia and Analgesia and serve to further complement the step-by-step guidelines contained in both the text and atlas. What's more, this all-new art program provides the best available coverage of regional anesthesia anatomy!

The Heart in End-stage Renal Failure

Etiology, Symptoms, and Management of Uremic Heart Disease

Author: V. Wizemann

Publisher: S Karger Ag

ISBN:

Category: Medical

Page: 149

View: 112

Oxford Textbook of Clinical Nephrology Volume 3

Author: Alex M. Davison

Publisher: Oxford University Press, USA

ISBN:

Category: Kidneys

Page: 2749

View: 590

Authoritative, well-written, and comprehensive textbook of clinical nephrology, combining the clinical aspects of renal disease important for daily clinical practice while giving extensive information about the underlying basic science and current evidence available. This new edition highlights the numerous changes in clinical management that have arisen as a result of recently concluded clinical trials and there are now specific formal guidelines for optimal treatment of patients. Each section of the textbook has been critically and comprehensively edited under the auspices of one of the leading experts in the field. The emphasis throughout is on marrying advances in scientific research with clinical managment. Where possible treatment algorithms are included to aid patient care.

Research Awards Index

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Category: Medicine

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Primer on Kidney Diseases

Author: Arthur Greenberg

Publisher: Elsevier Health Sciences

ISBN:

Category: Medical

Page: 608

View: 468

An official publication of the National Kidney Foundation (NKF), the book provides a current overview of the pathophysiology, diagnosis, and management of kidney diseases, fluid and electrolyte disorders, hypertension, dialysis, and kidney transplantation. Includes new chapters on pathogenesis and pathophysiology of diabetic nephropathy and genetic basis of glomerular and structural kidney disorders.

Molecular Mechanism of Fibrosis and Central Role of Cardiotonic Steroids in Uremic Cardiomyopathy

Author: Jihad Victor Elkareh

Publisher:

ISBN:

Category:

Page: 147

View: 995

It has been recognized that patients with chronic renal failure eventually develop diastolic dysfunction, cardiac hypertrophy and systemic oxidant stress along with increases in circulating concentrations of the cardiotonic steroid, marinobufagenin (MBG) in uremic cardiomyopathy. Because of this, we performed 5/6th partial nephrectomy in rats to study experimental renal failure (PNx), MBG infusion, PNx after immunization against MBG, and concomitant PNx and adrenalectomy. We also studied 5/6th partial nephrectomy as a potential experimental renal failure model in mice. Next, we speculated a relationship between decreases Fli-1 expression and increases in collagen production following exposure to MBG. Therefore, we examined Fli-1 knockdown mice and compared it to wild type mice. Physiological measurements with a Millar catheter and immunohistochemistry were performed. In vitro studies were then pursued with cultured isolated cardiac fibroblasts, human dermal fibroblasts, as well as a cell line derived from renal fibroblasts. First, in rats, we observed that PNx after immunization against MBG as well as concomitant PNx and adrenalectomy had similar blood pressure as PNx but less cardiac hypertrophy, diastolic dysfunction, and cardiac fibrosis. Second, in mice, the 5/6 nephrectomy resulted in impairment of both active and passive left ventricular relaxation at four weeks as well as progressive fibrosis in the heart. Third, the Fli-1 knockdown mice showed greater amounts of cardiac collagen expression and fibrosis compared to wild type before and after 4 weeks of experimental renal failure induced by 5/6th nephrectomy. We realized that stimulation of cultured cardiac fibroblasts with MBG could be prevented by administration of inhibitors of tyrosine phosphorylation, Src activation, EGFR transactivation, and N-acetyl cysteine. Furthermore, in response to MBG, decreases in nuclear Fli-1 accompanied increases in procollagen expression. Finally, we observed that exposure of cardiac fibroblasts to MBG was associated with a rapid translocation of PKC[delta] to the nucleus that appeared to peak at about 15 minutes as determined with confocal immunofluorescence and Western blot. Taken together, these data suggest that MBG directly induces increases in collagen expression by fibroblasts in a process involving Fli-1 and PKC[delta], and is in part responsible for the cardiac fibrosis seen with experimental renal failure.

Anesthesia and Uncommon Pediatric Diseases

Author: Jordan Katz

Publisher: W B Saunders Company

ISBN:

Category: Medical

Page: 549

View: 986

Co-morbidities in Heart Failure, An Issue of Heart Failure Clinics, E-Book

Author: Faiez Zannad

Publisher: Elsevier Health Sciences

ISBN:

Category: Medical

Page: 160

View: 377

This issue of Heart Failure Clinics examines co-morbidities in patients with heart failure. Topics include hypertension, diabetes, pulmonary disorders, cardiorenal syndrome, anemia, depression, atrial fibrillation, obesity and cardiac cachexia, peripheral vascular disease, rheumatologic disorders, co-morbidities and polypharmacy, coronary artery disease, and clinical trials.