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Neural and Endocrine Peptides and Receptors

Author: Terry W. Moody

Publisher: Springer

ISBN:

Category: Medical

Page: 734

View: 684

The Fifth Annual Washington Spring Symposium on Health Sciences attracted over 400 scientists from 20 countries. It was held at the Lisner Auditorium of the George Washington University in Washington. D.C. The theme of the meeting was neural and endocrine peptides and receptors. The meeting emphasized basic and clinical research on neural and endocrine peptides and receptors. The six plenary sessions emphasized pituitary peptides, releasing factors, brain peptides, growth factors, peripheral peptides, and clinical applications. The chapters in this volume are derived from each of these six scientific sessions plus the poster and special sessions. The Abraham White Distinguished Scientist A ward was presented to Dr. Julius Axelrod for his numerous contributions to the field of neurochemistry. He presented the keynote address, which was entitled "The Regulation of the Release of ACTH." Dr. Axelrod discussed numerous factors, such as the peptides CRF, VIP, and somatostatin, that regulate hormone secretion from pituitary cells. The Distinguished Public Service Award was presented to Senator Lowell Weicker, Jr., in recognition of his leadership and outstanding achievements in the United States Senate and for his legislative support for biomedical research and education. In the symposium banquet address, Senator Weicker stressed the need for continued federal support of biomedical science research.

Neural and Endocrine Peptides and Receptors

Author: Terry W. Moody

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 734

View: 946

The Fifth Annual Washington Spring Symposium on Health Sciences attracted over 400 scientists from 20 countries. It was held at the Lisner Auditorium of the George Washington University in Washington. D.C. The theme of the meeting was neural and endocrine peptides and receptors. The meeting emphasized basic and clinical research on neural and endocrine peptides and receptors. The six plenary sessions emphasized pituitary peptides, releasing factors, brain peptides, growth factors, peripheral peptides, and clinical applications. The chapters in this volume are derived from each of these six scientific sessions plus the poster and special sessions. The Abraham White Distinguished Scientist A ward was presented to Dr. Julius Axelrod for his numerous contributions to the field of neurochemistry. He presented the keynote address, which was entitled "The Regulation of the Release of ACTH." Dr. Axelrod discussed numerous factors, such as the peptides CRF, VIP, and somatostatin, that regulate hormone secretion from pituitary cells. The Distinguished Public Service Award was presented to Senator Lowell Weicker, Jr., in recognition of his leadership and outstanding achievements in the United States Senate and for his legislative support for biomedical research and education. In the symposium banquet address, Senator Weicker stressed the need for continued federal support of biomedical science research.

Neural and Endocrine Peptides and Receptors '85

Fifth International Washington Spring Symposium, Washington, D.C., May 28-31, 1985 : Abstract Volume

Author: George Washington University

Publisher:

ISBN:

Category: Endocrinology

Page: 137

View: 936

Neural and Endocrine Biology

Author: Stanley G. Schultz

Publisher: Amer Physiological Society

ISBN:

Category: Science

Page: 722

View: 863

This volume marks the coming of age of knowledge concerning the neural and endocrine biology of the gut. It is the first volume in the Handbook of Physiology to be devoted entirely to this field. It is also the very first volume ever published that deals systematically with the biochemistry, cell biology, molecular biology, pharmacology, and physiology of hormonal and neural peptides of the gut. Written by some forty recognized experts, Neural and Endocrine Biology details the discoveries of a field that is now just twenty-five years old. The early chapters address general topics and provide a broad overview of the field, including information on immunocytochemistry of endocrine cells and enteric neurons and the physiological significance of hormonal, paracrine, and neural peptides. Fourteen of the volume's twenty-eight chapters are devoted to individual hormonal and neural peptides--their distribution, pharmacology, and physiological and cellular functions. The final chapter offers an overview of recently discovered peptides, including pancreastatin and two neural peptides, galanin and calcitonin gene-related peptide (CGRP). Neural and Endocrine Biology will be a welcome new resource for graduate students, instructors, and active researchers and clinicians who need a complete, up-to-date reference in regulatory peptides and gastrointestinal physiology and pharmacology.

Neurobiology of Amino Acids, Peptides and Trophic Factors

Author: James A. Ferrendelli

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 272

View: 585

This volume represents the proceedings of the third in a series of annual inter national symposia. The first, The Neuroregulation of Autonomic, Endocrine, and Immune Systems, was held in Indianapolis in the fall of 1985. The second, Psychological and Biological Approaches to the Understanding of Human Disease, was held in Bielefeld, Germany in the fall of 1986. The theme of this series concerns the communication between the central nervous system and the other major systems of the body, and the purpose is to monitor the frontiers of research into these neuronal/hormonal regulatory interactions and their application to medicine. The present volume deals with the role of peptides and amino acids in these information transfer processes. Great strides have been made in exploring the important role of amino acids and pep tides in neuroregulation, and the ongoing biotechnology revolution promises signi ficant scientific and medical advances throughout the next decade and beyond. The work described in this volume captures the great excitement and pro mise of this biomedical renaissance. This meeting was cosponsored by Searle/ Monsanto and Washington University and held in St. Louis in the early fall of 1986. A major contributor to these proceedings was Dr. Thomas O'Donohue whose chapter deals with his work in characterizing the endogenous ligands for the PCP and sigma opioid receptors. Tom's personality and career personi fied the dedication of this series to the principle of a broad multidisciplinary approach to scientific problems.

Neural and Endocrine Biology

Author: Stanley G. Schultz

Publisher: Amer Physiological Society

ISBN:

Category: Science

Page: 722

View: 141

This volume marks the coming of age of knowledge concerning the neural and endocrine biology of the gut. It is the first volume in the Handbook of Physiology to be devoted entirely to this field. It is also the very first volume ever published that deals systematically with the biochemistry, cell biology, molecular biology, pharmacology, and physiology of hormonal and neural peptides of the gut. Written by some forty recognized experts, Neural and Endocrine Biology details the discoveries of a field that is now just twenty-five years old. The early chapters address general topics and provide a broad overview of the field, including information on immunocytochemistry of endocrine cells and enteric neurons and the physiological significance of hormonal, paracrine, and neural peptides. Fourteen of the volume's twenty-eight chapters are devoted to individual hormonal and neural peptides--their distribution, pharmacology, and physiological and cellular functions. The final chapter offers an overview of recently discovered peptides, including pancreastatin and two neural peptides, galanin and calcitonin gene-related peptide (CGRP). Neural and Endocrine Biology will be a welcome new resource for graduate students, instructors, and active researchers and clinicians who need a complete, up-to-date reference in regulatory peptides and gastrointestinal physiology and pharmacology.

Current Aspects of the Neurosciences

Volume 1

Author: Neville N. Osborne

Publisher: Macmillan International Higher Education

ISBN:

Category: Biochemistry

Page: 316

View: 254

Physiology and Pharmacology of the Blood-Brain Barrier

Author: Michael W.B. Bradbury

Publisher: Springer Science & Business Media

ISBN:

Category: Medical

Page: 549

View: 408

The blood-brain barrier is still not completely understood and therefore the subject of fascinating study. How are endogenous substances transported through the blood-brain barrier? What are the known therapeutic and toxic agents? How are they transported across cerebral microvessels? The discussion of these and other questions with far-reaching consequences for all neuroscientists can be found in this volume. This authoritative and up-to-date review of the blood-brain barrier gives a proper understanding of the topic. The experimental principles, the results of very recent research, as well as the implications that experimental research has for clinical treatment are thoroughly covered. Information is given on: - new findings based on classical physiological and pharmacological techniques, - results obtained from brain capillaries in vitro and in culture, - results obtained from the new scanning techniques (PET and MRI), - the immunology of the blood-brain barrier, - trace metal transport, - the pathological breakdown of the barrier and - the modification of drugs to increase their entry into the brain. Here is a source of information that is invaluable to specialists concerned with basic research in the neurosciences, with the design of neuropharmacological agents, with the radiological diagnosis of cerebral pathology or with the treatment of cerebral lesions!

The Regulation of a Post-Translational Peptide Acetyltransferase: Strategies for Selectively Modifying the Biological Activity of Neural and Endocrine Peptides

Author:

Publisher:

ISBN:

Category:

Page: 51

View: 243

The broad objective of this research is to develop new strategies for pharmacologically modifying synaptic transmission by pepti-dergic neurons. It is based on the principal that post-trans-lational processing determines the biological activity of neural and endocrine peptides and uses the beta-endorphin processing pathway as a model for study. Five primary objectives were met during the course of this research. First, we found that post-translational processing enzymes are selectively and individually regulated, which indicates that certain processing enzymes serve a rate limiting role in peptide biosynthesis, while others do not. Second, pharmacologic agents targeted on cell surface receptors selectively regulate beta-endorphin processing enzymes, producing distinct changes in the molecular forms and, hence, the biological activities of the beta-endorphin peptides released from the pituitary gland. Third, brain beta-endorphin processing is also regulated through receptor activation although, in general, it appears to be more resistant to this strategy, emphasizing the need to develop agents which control peptide processing through direct enzyme inhibition or activation. Fourth, we characterized the beta-endorphin processing.

Neural and Endocrine Biology

Author: Stanley G. Schultz

Publisher: Amer Physiological Society

ISBN:

Category: Science

Page: 722

View: 608

This volume marks the coming of age of knowledge concerning the neural and endocrine biology of the gut. It is the first volume in the Handbook of Physiology to be devoted entirely to this field. It is also the very first volume ever published that deals systematically with the biochemistry, cell biology, molecular biology, pharmacology, and physiology of hormonal and neural peptides of the gut. Written by some forty recognized experts, Neural and Endocrine Biology details the discoveries of a field that is now just twenty-five years old. The early chapters address general topics and provide a broad overview of the field, including information on immunocytochemistry of endocrine cells and enteric neurons and the physiological significance of hormonal, paracrine, and neural peptides. Fourteen of the volume's twenty-eight chapters are devoted to individual hormonal and neural peptides--their distribution, pharmacology, and physiological and cellular functions. The final chapter offers an overview of recently discovered peptides, including pancreastatin and two neural peptides, galanin and calcitonin gene-related peptide (CGRP). Neural and Endocrine Biology will be a welcome new resource for graduate students, instructors, and active researchers and clinicians who need a complete, up-to-date reference in regulatory peptides and gastrointestinal physiology and pharmacology.

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