Atherosclerosis is the principal underlying cause of cardiovascular and cerebrovascular disease in people of the Western world. Cigarette smoking has been implicated in both the initiation and exacerbation of the atherosclerotic process. Data to support this implication derives primarily from epidemiologic studies where the relationship between the incidence of atherosclerosis in people who smoke cigarettes has been shown to have a strong correlation. There are few well established explanations for this phenomenon, and basic molecular, biochemical, and cellular mechanisms associated with smoking and the development of atherosclerosis remain both undefined and virtually unexplored. Even the epidemiologic correlation between cigarette smoking and the development of atherosclerosis needs further critical studies. It is known that individuals who do not smoke cigarettes develop athero sclerosis and it is also known that in people who smoke but have normal or low blood cholesterol/lipoprotein levels, the incidence of development of atherosclerosis is no different from that which is found in a non smoking population. Answers which explain such observations must address fundamental biological mechanisms. Toward this end, the purpose of this volume is to assemble, in a single publication, information which will address the questions; what basic cellular and/or molecular mechanisms are associated with the development of atherosclerosis and how does cigarette smoking influence such mechanisms to initiate or exacerbate the atherosclerotic process? Clearly, the development of atherosclerosis is a complex, multifactorial biological event.
Analysis of the scientific evidence of the relationship between cigarette smoking and multiple cardiovascular diseases. Report clearly establishes that cigarette smoking increases the risk for a number of cardiovascular diseases. Demonstrates that cigarette smoking is a major risk factor in the U.S. Tables and figures. Bibliography. Index.
Publisher: Karger Medical and Scientific Publishers
Cigarette smoking is also a risk factor for diffuse atherosclerosis, ischemic heart disease and peripheral vascular lesions, renal microvessels being another potential target. Furthermore, the relationships of chronic cigarette smoking and nitric oxide with endothelial dysfunction and vascular disease are well proven, and the association between eNOS gene polymorphisms and vascular disease and their dependence on chronic tobacco smoking has been stressed. But although there is definite evidence that the risk of progression of acquired or genetic renal disease is higher in chronic cigarette smokers and the negative effect on patient survival in chronic dialytic treatment is well known, these issues are still neglected by clinical nephrologists and the mechanisms involved have not yet been classified.
The most important information you need to improve your health
Author: Adams Media
Publisher: Simon and Schuster
Category: Health & Fitness
Understanding heart disease is your first step in reversing or preventing a potentially life-threatening condition. The Everything® Healthy Living Series is here to help. These concise, thoughtful guides offer the expert advice and the latest medical information you need to manage your heart disease and lead a healthy life. It’s well known that carcinogens in cigarette smoke can cause cancer, but they can be equally damaging to your heart. Inside you’ll find useful information on the benefits of quitting, stop-smoking aids, and places to find help.
Arterial and venous diseases are major causes of morbidity and mortality in most of the world, especially in the western hemisphere. Not only of interest to angiologists, these illnesses are also of concern to most physicians in various fields ranging from cardiology, general medicine and cardiovascular surgery to physiology, pathology and clinical pharmacology. Specialists in diabetes, hypertension and epidemiology find these illnesses as challenging in their own fields of interest due to the gross interrelation of these diseases with their specialities.